Mitochondrial metabolic signatures in hepatocellular carcinoma

HY Lee, HT Nga, J Tian, HS Yi - Cells, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide.
HCC progression and metastasis are closely related to altered mitochondrial metabolism …

The metabolic fates of pyruvate in normal and neoplastic cells

EV Prochownik, H Wang - Cells, 2021 - mdpi.com
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of
glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed …

HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3‐mediated m6A modification of HIF‐1α

N Yang, T Wang, Q Li, F Han, Z Wang… - Journal of Cellular …, 2021 - Wiley Online Library
Cancer cells sustain high levels of glycolysis and glutaminolysis via reprogramming of
intracellular metabolism, which represents a driver of hepatocellular carcinoma (HCC) …

Construction of a lipid metabolism‐related and immune‐associated prognostic signature for hepatocellular carcinoma

B Hu, XB Yang, XT Sang - Cancer medicine, 2020 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. We
aimed to identify a robust lipid metabolism‐related signature associated with the HCC …

Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia

Y Hou, J **e, S Wang, D Li, L Wang, H Wang… - Cellular & molecular …, 2022 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells and natural inhibitors of adaptive immunity. Intracellular metabolic changes in MDSCs …

Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer Corrigendum in/10.3892/mmr. 2021.12359

L Qin, Z Zhan, C Wei, X Li… - Molecular medicine …, 2021 - spandidos-publications.com
In recent years, increasing evidence has confirmed that exosomal circular RNAs (circRNAs)
serve a crucial role in the prognostic prediction and diagnosis of liver cancer (LC). The …

Alterations of the gut microbiome and fecal metabolome in colorectal cancer: implication of intestinal metabolism for tumorigenesis

X Du, Q Li, Z Tang, L Yan, L Zhang, Q Zheng… - Frontiers in …, 2022 - frontiersin.org
Objective: The gut microbiota and its metabolites are important for host physiological
homeostasis, while dysbiosis is related to diseases including the development of cancers …

[HTML][HTML] Deletion of lactate dehydrogenase-a impairs oncogene-induced mouse hepatocellular carcinoma development

M Serra, M Di Matteo, J Serneels, R Pal… - Cellular and Molecular …, 2022 - Elsevier
Abstract Background and Aims Hepatocellular carcinoma (HCC) is a multistep process
whereby abnormally proliferating cancer cells undergo extensive metabolic reprogramming …

β-Catenin mutations as determinants of hepatoblastoma phenotypes in mice

W Zhang, J Meyfeldt, H Wang, S Kulkarni, J Lu… - Journal of Biological …, 2019 - ASBMB
Hepatoblastoma (HB) is the most common pediatric liver cancer. Although long-term survival
of HB is generally favorable, it depends on clinical stage, tumor histology, and a variety of …

[HTML][HTML] Coordinated cross-talk between the myc and mlx networks in liver regeneration and neoplasia

H Wang, J Lu, F Alencastro, A Roberts, J Fiedor… - Cellular and molecular …, 2022 - Elsevier
Background & Aims The c-Myc (Myc) Basic helix-loop-helix leucine zipper (bHLH-ZIP)
transcription factor is deregulated in most cancers. In association with Max, Myc controls …