The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver …

INTRODUCTION The liver's remarkable capacity to maintain proper tissue mass after injury
has been known since ancient times. However, there has been considerable debate about …

The mammalian liver possesses a remarkable regenerative ability. Two modes of damage
response have been described:(1) The" oval cell" response emanates from the biliary tree …

INTRODUCTION Cell proliferation is a fundamental process in all multicellular organisms
that is required to enable development, tissue homeostasis, tissue repair, and tissue …

Hepatocytes operate in highly structured repeating anatomical units termed liver lobules.
Blood flow along the lobule radial axis creates gradients of oxygen, nutrients and hormones …

The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

Histology imaging is an important tool in medical diagnosis and research, enabling the
examination of tissue structure and composition at the microscopic level. Understanding the …