Arachidonic acid (AA) metabolism is critical in the initiation and resolution of inflammation.
Prostaglandin E2 (PGE2) and leukotriene B4/D4/E4 (LTB4/LD4/LTE4), derived from AA, are …

Psoriasis is a chronic inflammatory skin disease characterized by accelerated tumor
necrosis factor-α/interleukin-23/interleukin-17 axis, hyperproliferation and abnormal …

Alopecia areata is a representative inflammatory skin disease that is associated with various
environmental stimuli. While psychological stress is believed to be a major pathogenetic …

Throughout life, it is necessary to adapt to the Earth's environment in order to survive. A
typical example of this is that the daily Earth cycle is different from the circadian rhythm in …

Skin immunity is regulated by many mediator molecules. One is the neuropeptide calcitonin
gene-related peptide (CGRP). CGRP has roles in regulating the function of components of …

An inflammatory response is beneficial to the organism, while an excessive uncontrolled
inflammatory response can lead to the nonspecific killing of tissue cells. Therefore …

Rationale: Psoriasis is a chronic inflammatory disease caused by a complex interplay
between the immune and nervous systems with recurrent scaly skin plaques, thickened …

Altered epidermal differentiation along with increased keratinocyte proliferation is a
characteristic feature of psoriasis and pityriasis rubra pilaris (PRP). However, despite this …

Autoimmune diseases are driven by TH17 cells that secrete pro-inflammatory cytokines,
especially IL-17. Under normal physiological conditions, autoreactive T cells are suppressed …

Background: Psoriasis is a chronic, immune-mediated inflammatory skin disease, and the
inflammatory response plays an important role in its development and progression. Datura …