Host genetics and infectious disease: new tools, insights and translational opportunities
Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …
Schizophrenia and influenza at the centenary of the 1918-1919 Spanish influenza pandemic: mechanisms of psychosis risk
Associations between influenza infection and psychosis have been reported since the
eighteenth century, with acute “psychoses of influenza” documented during multiple …
eighteenth century, with acute “psychoses of influenza” documented during multiple …
Human leukocyte antigen alleles associate with COVID-19 vaccine immunogenicity and risk of breakthrough infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine immunogenicity
varies between individuals, and immune responses correlate with vaccine efficacy. Using …
varies between individuals, and immune responses correlate with vaccine efficacy. Using …
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility
The COVID-19 pandemic has accounted for millions of infections and hundreds of thousand
deaths worldwide in a short-time period. The patients demonstrate a great diversity in …
deaths worldwide in a short-time period. The patients demonstrate a great diversity in …
The influence of HLA genotype on the severity of COVID‐19 infection
The impact of COVID‐19 varies markedly, not only between individual patients but also
between different populations. We hypothesised that differences in HLA genes might …
between different populations. We hypothesised that differences in HLA genes might …
Epidemiology of brain and other CNS tumors
Abstract Purpose of Review Brain and other central nervous system (CNS) tumors, while
rare, cause significant morbidity and mortality across all ages. This article summarizes the …
rare, cause significant morbidity and mortality across all ages. This article summarizes the …
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines
Background Humoral immune responses to infectious agents or vaccination vary
substantially among individuals, and many of the factors responsible for this variability …
substantially among individuals, and many of the factors responsible for this variability …
Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis
Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology
has remained controversial mainly due to the lack of serological methods that can …
has remained controversial mainly due to the lack of serological methods that can …
SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease
S Strausz, E Abner, G Blacker, S Galloway… - Nature …, 2024 - nature.com
Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host
factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using …
factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using …
Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations
Background Extranodal natural killer T-cell lymphoma (NKTCL; nasal type) is an aggressive
malignancy with a particularly high prevalence in Asian and Latin American populations …
malignancy with a particularly high prevalence in Asian and Latin American populations …