The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Preterm prelabor rupture of the membranes: a disease of the fetal membranes

R Menon, LS Richardson - Seminars in perinatology, 2017 - Elsevier
Preterm prelabor rupture of the membranes (pPROM) remains a significant obstetric
problem that affects 3–4% of all pregnancies and precedes 40–50% of all preterm births …

Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome

M Tchirikov, N Schlabritz-Loutsevitch… - Journal of perinatal …, 2018 - degruyter.com
Mid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal
membranes prior to 28 weeks of gestation, complicates approximately 0.4%–0.7% of all …

Bacterial vaginosis and health-associated bacteria modulate the immunometabolic landscape in 3D model of human cervix

P Łaniewski, MM Herbst-Kralovetz - npj Biofilms and Microbiomes, 2021 - nature.com
Bacterial vaginosis (BV) is an enigmatic polymicrobial condition characterized by a
depletion of health-associated Lactobacillus and an overgrowth of anaerobes. Importantly …

The role of nuclear factor kappa B in human labour

TM Lindstrom, PR Bennett - Reproduction, 2005 - rep.bioscientifica.com
Preterm birth remains the leading cause of perinatal mortality and morbidity, largely as a
result of a poor understanding of the precise mechanisms controlling labour onset in …

Invasion of the leukocytes into the fetal-maternal interface during pregnancy

N Gomez-Lopez, LJ Guilbert… - Journal of leukocyte …, 2010 - academic.oup.com
Review of mechanisms of uterine leukocyte infiltration and the potential roles of each
subpopulation of leukocytes in relation to pregnancy and parturition. No other organ in the …

New insights into the role of matrix metalloproteinases in preeclampsia

S Espino Y Sosa, A Flores-Pliego… - International Journal of …, 2017 - mdpi.com
Preeclampsia is a severe pregnancy complication globally, characterized by poor
placentation triggering vascular dysfunction. Matrix metalloproteinases (MMPs) exhibit …

Incidence of preterm premature rupture of membranes and its association with inter-pregnancy interval: a prospective cohort study

BH Jena, GA Biks, YK Gete, KA Gelaye - Scientific reports, 2022 - nature.com
Preterm premature rupture of membranes is one of the causes of premature birth and
perinatal deaths, particularly in develo** countries due to poor access and availability of …

The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited

D Kumar, RM Moore, BM Mercer, JM Mansour… - Placenta, 2016 - Elsevier
Rupture of the fetal membranes (FM) is precipitated by stretch forces acting upon
biochemically mediated, pre-weakened tissue. Term FM develop a para-cervical weak zone …

Landscape of preterm birth therapeutics and a path forward

BS Coler, O Shynlova, A Boros-Rausch, S Lye… - Journal of Clinical …, 2021 - mdpi.com
Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50
years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic …