A review of the current mammalian models of Alzheimer's disease and challenges that need to be overcome
NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …
lifespans and better medical treatment for other conditions mean that the prevalence of this …
Exploring advancements in early detection of Alzheimer's disease with molecular assays and animal models
Alzheimer's Disease (AD) is a challenging neurodegenerative condition, with overwhelming
implications for affected individuals and healthcare systems worldwide. Animal models have …
implications for affected individuals and healthcare systems worldwide. Animal models have …
[HTML][HTML] Aβ plaques
LC Walker - Free neuropathology, 2020 - ncbi.nlm.nih.gov
Aβ plaques are one of the two lesions in the brain that define the neuropathological
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …
diagnosis of Alzheimer's disease. Plaques are highly diverse structures; many of them …
Clinical relevance of animal models in aging-related dementia research
Alzheimer's disease (AD) and other, less prevalent dementias are complex age-related
disorders that exhibit multiple etiologies. Over the past decades, animal models have …
disorders that exhibit multiple etiologies. Over the past decades, animal models have …
Genetically modified large animal models for investigating neurodegenerative diseases
Neurodegenerative diseases represent a large group of neurological disorders including
Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's …
Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's …
What's that (blue) spot on my MRI? Multimodal neuroimaging of the locus coeruleus in neurodegenerative disease
The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …
Application of CRISPR/Cas9 system in establishing large animal models
Y Lin, J Li, C Li, Z Tu, S Li, XJ Li, S Yan - Frontiers in Cell and …, 2022 - frontiersin.org
The foundation for investigating the mechanisms of human diseases is the establishment of
animal models, which are also widely used in agricultural industry, pharmaceutical …
animal models, which are also widely used in agricultural industry, pharmaceutical …
Deconstructing Alzheimer's disease: how to bridge the gap between experimental models and the human pathology?
A Vignon, L Salvador-Prince, S Lehmann… - International journal of …, 2021 - mdpi.com
Discovered more than a century ago, Alzheimer's disease (AD) is not only still present in our
societies but has also become the most common dementia, with 50 million people …
societies but has also become the most common dementia, with 50 million people …
Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter.
Alzheimer's disease (AD) is the leading cause of dementia which afflicts tens of millions of
people worldwide. Despite many scientific progresses to dissect the AD's molecular basis …
people worldwide. Despite many scientific progresses to dissect the AD's molecular basis …
A nonhuman primate model with Alzheimer's disease-like pathology induced by hippocampal overexpression of human tau
Z Jiang, J Wang, Y Qin, S Liu, B Luo, F Bai… - Alzheimer's Research & …, 2024 - Springer
Background Alzheimer's disease (AD) is one of the most burdening diseases of the century
with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic …
with no disease-modifying treatment at this time. Nonhuman primates (NHPs) share genetic …