Italy is definitely a high-risk country for multiple sclerosis (MS). Over the last 50 years,
several epidemiological studies, including longitudinal surveys, have disclosed that MS …

Signatures of positive selection in the genome are a characteristic mark of adaptation that
can reveal an ongoing, recent, or ancient response to environmental change throughout the …

The origin, development, and legacy of the enigmatic Etruscan civilization from the central
region of the Italian peninsula known as Etruria have been debated for centuries. Here we …

Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …

As an initial step in more extensive research into the links between biological and cultural
diversity in present-day Italy, we reviewed Biocultural Diversity studies that explore the …

Human APOE is a 299-amino acid long protein expressed and secreted in several tissues
and body districts, where it exerts different functions mainly related to lipid metabolism, with …

Mutation A713T in the amyloid precursor protein (APP) has been linked to cases of
Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA) and cerebrovascular disease …

Abstract The Italian Peninsula, a natural pier across the Mediterranean Sea, witnessed
intricate population events since the very beginning of the human occupation in Europe. In …

Umbria is located in Central Italy and took the name from its ancient inhabitants, the Umbri,
whose origins are still debated. Here, we investigated the mitochondrial DNA (mtDNA) …

Leukocyte telomere length (LTL) represents a key integrating component of the cumulative
effects of environmental, lifestyle, and genetic factors. A question, however, remains on …