[HTML][HTML] Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip …
Developmental toxicity testing urgently requires the implementation of human-relevant new
approach methodologies (NAMs) that better recapitulate the peculiar nature of human …
approach methodologies (NAMs) that better recapitulate the peculiar nature of human …
An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods
The main available alternatives for testing embryotoxicity are cellular tests with stem cells
and in vitro-ex vivo tests with embryos. In cellular tests, the most developed alternative is the …
and in vitro-ex vivo tests with embryos. In cellular tests, the most developed alternative is the …
Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells
Pluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we
established a novel culture system to differentiate human embryonic stem cell aggregates …
established a novel culture system to differentiate human embryonic stem cell aggregates …
Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes
LL Tang, JD Wang, TT Xu, Z Zhao, JJ Zheng, RS Ge… - Toxicology, 2017 - Elsevier
Perfluorooctane sulfonate (PFOS) is a persistent organic contaminant that may cause
cardiotoxicity in animals and humans. However, little is known about the underlying …
cardiotoxicity in animals and humans. However, little is known about the underlying …
From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and …
The superordinate principles governing the transcriptome response of differentiating cells
exposed to drugs are still unclear. Often, it is assumed that toxicogenomics data reflect the …
exposed to drugs are still unclear. Often, it is assumed that toxicogenomics data reflect the …
[HTML][HTML] Pluripotent stem cell assays: Modalities and applications for predictive developmental toxicity
This manuscript provides a review focused on embryonic stem cell-based models and their
place within the landscape of alternative developmental toxicity assays. Against the …
place within the landscape of alternative developmental toxicity assays. Against the …
Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants
J Nyffeler, C Karreman, H Leisner, YJ Kim, G Lee… - 2017 - kops.uni-konstanz.de
Migration of neural crest cells (NCCs) is one of the pivotal processes of human fetal
development. Malformations arise, if NCC migration and differentiation are impaired …
development. Malformations arise, if NCC migration and differentiation are impaired …
Using a multi-stage hESC model to characterize BDE-47 toxicity during neurogenesis
H Chen, H Seifikar, N Larocque, Y Kim… - Toxicological …, 2019 - academic.oup.com
Although the ramifications associated with polybrominated diphenyl ethers (PBDEs)
exposures during human pregnancy have yet to be determined, increasing evidence in …
exposures during human pregnancy have yet to be determined, increasing evidence in …
Perfluorooctane sulfonate induced toxicity in embryonic stem cell-derived cardiomyocytes via inhibiting autophagy-lysosome pathway
D Liu, NY Liu, LT Chen, Y Shao, XM Shi, DY Zhu - Toxicology In Vitro, 2020 - Elsevier
Perfluorooctane sulfonate (PFOS), a classic environmental pollutant, is reported to cause
cardiotoxicity in animals and humans. It has been demonstrated that PFOS exposure down …
cardiotoxicity in animals and humans. It has been demonstrated that PFOS exposure down …
Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing
EVS Hessel, YCM Staal, AH Piersma - Toxicology and applied …, 2018 - Elsevier
Developmental neurotoxicity entails one of the most complex areas in toxicology. Animal
studies provide only limited information as to human relevance. A multitude of alternative …
studies provide only limited information as to human relevance. A multitude of alternative …