Stroke is the world's second leading cause of mortality, with a high incidence of severe
morbidity in surviving victims. There are currently relatively few treatment options available …

Integrated approaches using different in vitro methods in combination with bioinformatics
can (i) increase the success rate and speed of drug development;(ii) improve the accuracy of …

In its classic hormonal role, erythropoietin (EPO) is produced by the kidney and regulates
the number of erythrocytes within the circulation to provide adequate tissue oxygenation …

Nicotinamide, the amide form of vitamin B3 (niacin), is changed to its mononucleotide
compound with the enzyme nicotinic acide/nicotinamide adenylyl-transferase, and …

Erythropoietin (Epo) is an essential hormone that binds and activates the Epo receptor
(EpoR) resident on the surface of erythroid progenitor cells, thereby promoting …

Tissue injury, hypoxia and significant metabolic stress activate innate immune responses
driven by tumor necrosis factor (TNF)-α and other proinflammatory cytokines that typically …

Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also
appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral …

Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation
and progression of varied disorders throughout the body. It therefore becomes imperative to …

Unmitigated oxidative stress can lead to diminished cellular longevity, accelerated aging,
and accumulated toxic effects for an organism. Current investigations further suggest the …

Background An ancillary study of the High-Dose Erythropoietin for Asphyxia and
Encephalopathy (HEAL) trial for neonates with hypoxic-ischemic encephalopathy (HIE) and …