Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

We have designed a system for targeted gene expression that allows the selective activation
of any cloned gene in a wide variety of tissueand cell-specific patterns. The gene encoding …

DNA SHUFFLING is a method for in vitro homologous recombination of pools of selected
mutant genes by random fragmentation and polymerase chain reaction (PCR) reassembly1 …

The heat-shock protein Hsp90 supports diverse but specific signal transducers and lies at
the interface of several developmental pathways. We report here that when Drosophila …

Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

GTPases of the Ras superfamily regulate many aspects of cell growth, differentiation and
action. Their functions depend on their ability to alternate between inactive and active forms …

We have identified proteins that interact with H-Ras using a two hybrid system screen of a
mouse cDNA library. Approximately 50% of the clones identified encoded portionsof the c …

Areas and pathways subserving object and spatial vision are segregated in the visual
system. Experiments show that the primate prefrontal cortex is similarly segregated into …

We have isolated the" complete" repertoire of genes encoding the odorant receptors in
Drosophila and employ these genes to provide a molecular description of the organization …