The respiratory system acts as both the primary site of gas exchange and an important
sensor and barrier to the external environment. The increase in incidences of respiratory …

Over the last decade, single-cell genomics has revealed remarkable heterogeneity and
plasticity of cell types in the lungs and airways. The challenge now is to understand how …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Abstract Alveolar epithelial type 1 (AT1) cells are necessary to transfer oxygen and carbon
dioxide between the blood and air. Alveolar epithelial type 2 (AT2) cells serve as a partially …

Exaggerated airway constriction triggered by repeated exposure to allergen, also called
hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Accurate cell type identification is a key and rate-limiting step in single-cell data analysis.
Single-cell references with comprehensive cell types, reproducible and functionally …

Organ regeneration requires dynamic cell interactions to reestablish cell numbers and tissue
architecture. While we know the identity of progenitor cells that replace lost tissue, the …

Lung epithelial regeneration after acute injury requires coordination cellular coordination to
pattern the morphologically complex alveolar gas exchange surface. During adult lung …

The mammalian lung has an enormous environmental-epithelial interface that is optimized
to accomplish the principal function of the respiratory system, gas exchange. One …