Detection of human disease conditions by single-cell morpho-rheological phenoty** of blood

N Toepfner, C Herold, O Otto, P Rosendahl, A Jacobi… - elife, 2018 - elifesciences.org
Blood is arguably the most important bodily fluid and its analysis provides crucial health
status information. A first routine measure to narrow down diagnosis in clinical practice is the …

Human red blood cell membrane stiffness: why should we study it and how?

R Selvan, S Bhattacharya - The European Physical Journal Special Topics, 2024 - Springer
The primary function of the human red blood cells (RBCs) is to transport oxygen to all tissues
in the human body for the process of cellular respiration. To do this, RBCs often need to …

P. falciparum Invasion and Erythrocyte Aging

MF Alves-Rosa, NM Tayler, D Dorta, LM Coronado… - Cells, 2024 - mdpi.com
Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose
receptors for the pathogen ligands and, on the other hand, maintain the right geometry to …

Dielectric characterization of Plasmodium falciparum-infected red blood cells using microfluidic impedance cytometry

C Honrado, L Ciuffreda, D Spencer… - Journal of The …, 2018 - royalsocietypublishing.org
Although malaria is the world's most life-threatening parasitic disease, there is no clear
understanding of how certain biophysical properties of infected cells change during the …

Insights into physiological roles of unique metabolites released from Plasmodium-infected RBCs and their potential as clinical biomarkers for malaria

D Beri, G Ramdani, B Balan, D Gadara, M Poojary… - Scientific reports, 2019 - nature.com
Plasmodium sp. are obligate intracellular parasites that derive most of their nutrients from
their host meaning the metabolic circuitry of both are intricately linked. We employed …

[PDF][PDF] ATP, an extracellular signaling molecule in red blood cells: a messenger for malaria?

G Ramdani, G Langsley - Biomedical journal, 2014 - biomedj.cgu.edu.tw
However, this is not the only function of these abundant enucleated cells, whose cytoplasm
is rich in hemoglobin and poor in organelles; they are also redoubtable sensors of oxygen …

Studying the rigidity of red blood cells induced by Plasmodium falciparum infection

A Paul, G Ramdani, U Tatu, G Langsley, V Natarajan - Scientific reports, 2019 - nature.com
We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs)
induced by Plasmodium falciparum infection, and the bystander effect previously found. The …

Evidencing the role of erythrocytic apoptosis in malarial anemia

PRR Totino, CT Daniel-Ribeiro… - Frontiers in Cellular …, 2016 - frontiersin.org
In the last decade it has become clear that, similarly to nucleated cells, enucleated red blood
cells (RBCs) are susceptible to programmed apoptotic cell death. Erythrocytic apoptosis …

Optical tweezers to measure the elasticity of red blood cells: A tool to study the erythrocyte response to antimalarials

D Dorta, P Padmore, R Correa, L Pineda… - Frontiers in …, 2024 - frontiersin.org
The Plasmodium falciparum parasite infected more than 240 million people and killed
around 600,000 patients last year alone. A key aspect of the pathophysiology of P …

[HTML][HTML] Diagnosis of malarial infection using change in properties of optically trapped red blood cells

A Paul, P Padmapriya, V Natarajan - Biomedical journal, 2017 - Elsevier
Background In previous work studying the properties of red blood cells (RBCs) held in an
optical tweezers trap, we observed an increase in the spectrum of Brownian fluctuations for …