Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

MD Roberts, JJ McCarthy… - Physiological …, 2023 - journals.physiology.org
Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

JA Batsis, DT Villareal - Nature Reviews Endocrinology, 2018 - nature.com
The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle
mass and strength or physical function) is increasing in adults aged 65 years and older. A …

[HTML][HTML] Stimuli and sensors that initiate skeletal muscle hypertrophy following resistance exercise

H Wackerhage, BJ Schoenfeld… - Journal of applied …, 2019 - journals.physiology.org
One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

[HTML][HTML] Anabolic resistance in the pathogenesis of sarcopenia in the elderly: role of nutrition and exercise in young and old people

C Tezze, M Sandri, P Tessari - Nutrients, 2023 - mdpi.com
The development of sarcopenia in the elderly is associated with many potential factors
and/or processes that impair the renovation and maintenance of skeletal muscle mass and …

[HTML][HTML] Integrative biology of exercise

JA Hawley, M Hargreaves, MJ Joyner, JR Zierath - Cell, 2014 - cell.com
Exercise represents a major challenge to whole-body homeostasis provoking widespread
perturbations in numerous cells, tissues, and organs that are caused by or are a response to …

Targeting ageing with rapamycin and its derivatives in humans: a systematic review

DJW Lee, AH Kuerec, AB Maier - The Lancet Healthy Longevity, 2024 - thelancet.com
Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the
ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the …

An evidence-based narrative review of mechanisms of resistance exercise–induced human skeletal muscle hypertrophy

C Lim, EA Nunes, BS Currier… - … and science in …, 2022 - pmc.ncbi.nlm.nih.gov
Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

How much protein can the body use in a single meal for muscle-building? Implications for daily protein distribution

BJ Schoenfeld, AA Aragon - Journal of the International Society of …, 2018 - Taylor & Francis
Controversy exists about the maximum amount of protein that can be utilized for lean tissue-
building purposes in a single meal for those involved in regimented resistance training. It …

The influence of omega-3 fatty acids on skeletal muscle protein turnover in health, disuse, and disease

C McGlory, PC Calder, EA Nunes - Frontiers in nutrition, 2019 - frontiersin.org
Ingestion of omega-3 fatty acids is known to exert favorable health effects on a number of
biological processes such as improved immune profile, enhanced cognition, and optimized …

The role of exercise-induced myokines in regulating metabolism

JY Huh - Archives of pharmacal research, 2018 - Springer
Exercise has beneficial effects in ameliorating metabolic disorders, and a combined
therapeutic regimen of regular exercise and pharmaceutical treatment is often …