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Oxidative stress and diseases associated with high-altitude exposure
Several diseases associated with high-altitude exposure affect unacclimated individuals.
These diseases include acute mountain sickness (AMS), high-altitude cerebral edema …
These diseases include acute mountain sickness (AMS), high-altitude cerebral edema …
Hypoxic pulmonary vasoconstriction
JT Sylvester, LA Shimoda, PI Aaronson… - Physiological …, 2012 - journals.physiology.org
It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
Because MYC plays a causal role in many human cancers, including those with hypoxic and
nutrient-poor tumor microenvironments, we have determined the metabolic responses of a …
nutrient-poor tumor microenvironments, we have determined the metabolic responses of a …
Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: new findings for an old problem
Hypoxic pulmonary vasoconstriction (HPV) normally optimises ventilation–perfusion
matching in the lung, but leads to pulmonary hypertension (PH) under conditions of global …
matching in the lung, but leads to pulmonary hypertension (PH) under conditions of global …
Systematic understanding of pathophysiological mechanisms of oxidative stress-related conditions—diabetes mellitus, cardiovascular diseases, and ischemia …
Reactive oxygen species (ROS) plays a role in intracellular signal transduction under
physiological conditions while also playing an essential role in diseases such as …
physiological conditions while also playing an essential role in diseases such as …
Pulmonary hypertension in obstructive sleep apnea: is it clinically significant? A critical analysis of the association and pathophysiology
The development of pulmonary hypertension is a poor prognostic sign in patients with
obstructive sleep apnea (OSA) and affects both mortality and quality of life. Although …
obstructive sleep apnea (OSA) and affects both mortality and quality of life. Although …
Oxidative stress, kinase activation, and inflammatory pathways involved in effects on smooth muscle cells during pulmonary artery hypertension under hypobaric …
High-altitude exposure results in hypobaric hypoxia, which affects organisms by activating
several mechanisms at the physiological, cellular, and molecular levels and triggering the …
several mechanisms at the physiological, cellular, and molecular levels and triggering the …
Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia
Recent evidence supports a prominent role for Rho kinase (ROK)-mediated pulmonary
vasoconstriction in the development and maintenance of chronic hypoxia (CH)-induced …
vasoconstriction in the development and maintenance of chronic hypoxia (CH)-induced …
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts
The NADPH oxidases are involved in vascular remodeling processes and oxygen sensing.
Hypoxia-induced pulmonary arterial remodeling results in thickening of the vessel wall and …
Hypoxia-induced pulmonary arterial remodeling results in thickening of the vessel wall and …
Mechanobiology of microvascular function and structure in health and disease: focus on the coronary circulation
The coronary microvasculature plays a key role in regulating the tight coupling between
myocardial perfusion and myocardial oxygen demand across a wide range of cardiac …
myocardial perfusion and myocardial oxygen demand across a wide range of cardiac …