FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Members of the class O of forkhead box transcription factors (FoxO) have important roles in
metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of …

To understand the role of FoxO family members in hematopoiesis, we conditionally deleted
FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited …

As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR)
expression in key metabolic tissues may contribute to circadian entrainment of nutrient and …

Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in
response to the endocrine GH stimulus, but it is also secreted by multiple tissues for …

FoxO (forkhead box O; forkhead members of the O class) are transcription factors that
function under the control of insulin/insulin-like signalling. FoxO factors have been …

Foxo transcription factors have a conserved role in the adaptation of cells and organisms to
nutrient and growth factor availability. Here we show that Foxo1 has a crucial, nonredundant …

Reactive oxygen species (ROS) and cellular oxidative stress are involved in many
physiological and pathophysiological processes, including cellular and organismal aging …

Recent evidence suggests that oxidative stress contributes significantly to the regulation of
hematopoietic cell homeostasis. In particular, red blood cells and hematopoietic stem cells …

Activation of phosphoinositide 3-kinase (PI3K) is required for B cell proliferation and
survival. PI3K signaling also controls key aspects of B cell differentiation. Upon engagement …