Stem cells, hematopoiesis and lineage tracing: transplantation-centric views and beyond
A Konturek-Ciesla, D Bryder - Frontiers in cell and developmental …, 2022 - frontiersin.org
An appropriate production of mature blood cells, or hematopoiesis, is essential for
organismal health and homeostasis. In this developmental cascade, hematopoietic stem …
organismal health and homeostasis. In this developmental cascade, hematopoietic stem …
Clonal-level lineage commitment pathways of hematopoietic stem cells in vivo
While the aggregate differentiation of the hematopoietic stem cell (HSC) population has
been extensively studied, little is known about the lineage commitment process of individual …
been extensively studied, little is known about the lineage commitment process of individual …
Deciphering intratumoral heterogeneity using integrated clonal tracking and single-cell transcriptome analyses
Cellular heterogeneity is a major cause of treatment resistance in cancer. Despite recent
advances in single-cell genomic and transcriptomic sequencing, it remains difficult to relate …
advances in single-cell genomic and transcriptomic sequencing, it remains difficult to relate …
Host and graft factors impacting infection risk in hematopoietic cell transplantation
RL Kao, SG Holtan - Infectious Disease Clinics, 2019 - id.theclinics.com
Infect Dis Clin N Am 33 (2019) 311–329 https://doi. org/10.1016/j. idc. 2019.02. 001 id.
theclinics. com 0891-5520/19/© 2019 Elsevier Inc. All rights reserved. bone marrow infusion …
theclinics. com 0891-5520/19/© 2019 Elsevier Inc. All rights reserved. bone marrow infusion …
Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells
The age-associated decline in immunity manifests as imbalanced adaptive and innate
immune cells, which originate from the aging of the stem cells that sustain their regeneration …
immune cells, which originate from the aging of the stem cells that sustain their regeneration …
Quantitative association between gene expression and blood cell production of individual hematopoietic stem cells in mice
Individual hematopoietic stem cells (HSCs) produce different amounts of blood cells upon
transplantation. Taking advantage of the intercellular variation, we developed an …
transplantation. Taking advantage of the intercellular variation, we developed an …
The impact of aging on primate hematopoiesis as interrogated by clonal tracking
Age-associated changes in hematopoietic stem and progenitor cells (HSPCs) have been
carefully documented in mouse models but poorly characterized in primates and humans …
carefully documented in mouse models but poorly characterized in primates and humans …
Clonal tracking using embedded viral barcoding and high-throughput sequencing
Embedded viral barcoding in combination with high-throughput sequencing is a powerful
technology with which to track single-cell clones. It can provide clonal-level insights into …
technology with which to track single-cell clones. It can provide clonal-level insights into …
A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis
Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in
response to environmental signals. In many cases, cell-cell communication alters the …
response to environmental signals. In many cases, cell-cell communication alters the …
Lineage tracking to reveal the fate of hematopoietic stem cells influenced by Flk2− multipotent progenitors after transplantation
Z Wang, D Jiang, M Vergel-Rodriguez… - … & Molecular Medicine, 2023 - nature.com
After transplantation, hematopoietic stem cells (HSCs) sustain blood cell regeneration
throughout the patient's life. Recent studies suggest that several types of mature blood cells …
throughout the patient's life. Recent studies suggest that several types of mature blood cells …