Understanding biological mechanisms is fundamental for improving animal production and
health to meet the growing demand for high-quality protein. As an emerging biotechnology …

Over the past decade, with the development of high-throughput single-cell sequencing
technology, single-cell omics has been emerged as a powerful tool to understand the …

Pigs are valuable large animal models for biomedical and genetic research, but insights into
the tissue-and cell-type-specific transcriptome and heterogeneity remain limited. By …

The availability of viral entry factors is a prerequisite for the cross-species transmission of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell …

Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte
function is challenging as the intestine contains a vastly heterogeneous mixture of cells. Pigs …

It is a challenge to efficiently integrate and present the tremendous amounts of single-cell
data generated from multiple tissues of various species. Here, we create a new database …

The postnatal development of the liver, an essential organ for metabolism and immunity,
remains poorly characterized at the single-cell resolution. Here, we generated single …

Recently, single-cell RNA sequencing (scRNA-seq) provides unprecedented power for
accurately understanding gene expression regulatory mechanisms. However, scRNA-seq …

The genetically engineered pig is regarded as an optimal source of organ transplantation for
humans and an excellent model for human disease research, given its comparable …

Understanding the phenotypic and functional diversity of cerebral cortical GABAergic
neurons requires a comprehensive analysis of key transcriptional signatures and neuronal …