Immune-microbe interactions early in life: A determinant of health and disease long term
P Brodin - Science, 2022 - science.org
Research on newborn immunity has revealed the importance of cell ontogeny, feto-maternal
tolerance, and the transfer of maternal antibodies. Less is known about postnatal adaptation …
tolerance, and the transfer of maternal antibodies. Less is known about postnatal adaptation …
The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
Viable bacterial colonization is highly limited in the human intestine in utero
E Rackaityte, J Halkias, EM Fukui, VF Mendoza… - Nature medicine, 2020 - nature.com
Mucosal immunity develops in the human fetal intestine by 11–14 weeks of gestation, yet
whether viable microbes exist in utero and interact with the intestinal immune system is …
whether viable microbes exist in utero and interact with the intestinal immune system is …
Pathogenesis of preterm birth: bidirectional inflammation in mother and fetus
ES Green, PC Arck - Seminars in immunopathology, 2020 - Springer
Abstract Preterm birth (PTB) complicates 5–18% of pregnancies globally and is a leading
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …
cause of maternal and fetal morbidity and mortality. Most PTB is spontaneous and idiopathic …
The maternal gut microbiome in pregnancy: implications for the develo** immune system
The gut microbiome has important roles in host metabolism and immunity, and microbial
dysbiosis affects human physiology and health. Maternal immunity and microbial …
dysbiosis affects human physiology and health. Maternal immunity and microbial …
Mechanisms of fetal T cell tolerance and immune regulation
E Rackaityte, J Halkias - Frontiers in immunology, 2020 - frontiersin.org
The develo** human fetus generates both tolerogenic and protective immune responses
in response to the unique requirements of gestation. Thus, a successful human pregnancy …
in response to the unique requirements of gestation. Thus, a successful human pregnancy …
Vertically transferred maternal immune cells promote neonatal immunity against early life infections
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus.
The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly …
The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly …
Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes
Background Intra-amniotic infection is present in 10% of patients with an episode of preterm
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality …
[HTML][HTML] Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury
Macrophages are commonly thought to contribute to the pathophysiology of preterm labor by
amplifying inflammation—but a protective role has not previously been considered to our …
amplifying inflammation—but a protective role has not previously been considered to our …
Training the fetal immune system through maternal inflammation—a layered hygiene hypothesis
Over the last century, the alarming surge in allergy and autoimmune disease has led to the
hypothesis that decreasing exposure to microbes, which has accompanied industrialization …
hypothesis that decreasing exposure to microbes, which has accompanied industrialization …