Recent developments in isolating methods for exosomes

J Gao, A Li, J Hu, L Feng, L Liu, Z Shen - Frontiers in bioengineering …, 2023‏ - frontiersin.org
Exosomes are the smallest extracellular vesicles that can be released by practically all cell
types, and range in size from 30 nm to 150 nm. As the major marker of liquid biopsies …

MitoEVs: a new player in multiple disease pathology and treatment

X Zhou, S Liu, Y Lu, M Wan, J Cheng… - Journal of extracellular …, 2023‏ - Wiley Online Library
Mitochondrial damage plays vital roles in the pathology of many diseases, such as cancers,
neurodegenerative diseases, aging, metabolic diseases and many types of organ injury …

The role and applications of extracellular vesicles in osteoporosis

F Fang, J Yang, J Wang, T Li, E Wang, D Zhang, X Liu… - Bone research, 2024‏ - nature.com
Osteoporosis is a widely observed condition characterized by the systemic deterioration of
bone mass and microarchitecture, which increases patient susceptibility to fragile fractures …

Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications

C Yang, Y Xue, Y Duan, C Mao, M Wan - Journal of Controlled Release, 2024‏ - Elsevier
Extracellular vesicles are nanoscale vesicles that can be secreted by all cell types, are
intracellular in origin and have the same composition as their parent cells, play a key role in …

Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease

SL Fowler, TS Behr, E Turkes, DP O'Brien… - Nature …, 2024‏ - nature.com
The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple
neurodegenerative diseases, including Alzheimer's disease (AD). Assembled tau associates …

Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity

P D'Acunzo, EK Argyrousi, JM Ungania, Y Kim… - Molecular …, 2024‏ - Springer
Background Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and
in neurodegenerative disorders, including in Alzheimer's disease, in Down syndrome, and in …

[HTML][HTML] Mitochondrial-derived vesicles: the good, the bad, and the ugly

A Picca, F Guerra, R Calvani, HJ Coelho-Júnior… - International Journal of …, 2023‏ - mdpi.com
Mitophagy is crucial for maintaining mitochondrial quality. However, its assessment in vivo is
challenging. The endosomal–lysosomal system is a more accessible pathway through …

[HTML][HTML] Regenerative endodontic therapy: from laboratory bench to clinical practice

X Shi, X Hu, N Jiang, J Mao - Journal of advanced research, 2024‏ - Elsevier
Background Maintaining the vitality and functionality of dental pulp is paramount for tooth
integrity, longevity, and homeostasis. Aiming to treat irreversible pulpitis and necrosis, there …

PD-1/CD80+ small extracellular vesicles from immunocytes induce cold tumours featured with enhanced adaptive immunosuppression

LZ Zhang, JG Yang, GL Chen, QH **e, QY Fu… - Nature …, 2024‏ - nature.com
Only a minority of cancer patients benefit from immune checkpoint blockade therapy.
Sophisticated cross-talk among different immune checkpoint pathways as well as interaction …

M2 microglial extracellular vesicles attenuated blood-brain barrier disruption via MiR-23a-5p in cerebral ischemic mice

JJ Pan, L Qi, L Wang, C Liu, Y Song… - Aging and …, 2024‏ - pmc.ncbi.nlm.nih.gov
Protecting the integrity of the blood-brain barrier (BBB) is crucial for maintaining brain
homeostasis after ischemic stroke. Previous studies showed that M2 microglial extracellular …