Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

[Frontiers in Bioscience 13, 1619-1633, January 1, 2008] 1619 Humanization of antibodies
Juan C. Almagro1, Johan Fransson2 1 Page 1 [Frontiers in Bioscience 13, 1619-1633, January …

Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

Abstract IMGT/V-QUEST is the highly customized and integrated system for the standardized
analysis of the immunoglobulin (IG) and T cell receptor (TR) rearranged nucleotide …

IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org) is the
global reference in immunogenetics and immunoinformatics. By its creation in 1989 by …

IMGT®, the international ImMunoGeneTics information system®(http://www. imgt. org), was
created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGénétique Moléculaire LIGM …

B cells play a central role in humoral immunity but also have antibody-independent
functions. Studies to date have focused on B cells in blood and secondary lymphoid organs …

Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated
immune dysfunction. Current spatially resolved transcriptomic technologies are unable to …

Monoclonal antibodies play an increasingly important role for the development of new drugs
across multiple therapy areas. The term 'developability'encompasses the feasibility of …