[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy
CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …
The immune microenvironment in head and neck squamous cell carcinoma: on subsets and subsites
NE Wondergem, IH Nauta, T Muijlwijk… - Current oncology …, 2020 - Springer
Purpose To understand why some patients respond to immunotherapy but many do not, a
clear picture of the tumor microenvironment (TME) of head and neck squamous cell …
clear picture of the tumor microenvironment (TME) of head and neck squamous cell …
Chemistry42: an AI-driven platform for molecular design and optimization
Chemistry42 is a software platform for de novo small molecule design and optimization that
integrates Artificial Intelligence (AI) techniques with computational and medicinal chemistry …
integrates Artificial Intelligence (AI) techniques with computational and medicinal chemistry …
Somatic 9p24.1 alterations in HPV– head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity
Somatic copy number alterations (SCNAs), generally losses containing interferons and
interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune …
interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune …
Nivolumab for patients with high-risk oral leukoplakia: A nonrandomized controlled trial
Importance Proliferative verrucous leukoplakia (PVL) is an aggressive oral precancerous
disease characterized by a high risk of transformation to invasive oral squamous cell …
disease characterized by a high risk of transformation to invasive oral squamous cell …
The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors
Abstract NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …
(NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar …
Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma
Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To
develop targeted treatments, it is important to understand the transcriptomic consequences …
develop targeted treatments, it is important to understand the transcriptomic consequences …
[HTML][HTML] EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients
G Zhu, L Pei, Y Li, X Gou - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
Bladder cancer is a leading cause of morbidity and mortality worldwide. Currently,
immunotherapy has become a worthwhile therapy for bladder cancer. Tumor mutation …
immunotherapy has become a worthwhile therapy for bladder cancer. Tumor mutation …
Hallmarks of a genomically distinct subclass of head and neck cancer
T Muijlwijk, IH Nauta, A van der Lee… - Nature …, 2024 - nature.com
Cancer is caused by an accumulation of somatic mutations and copy number alterations
(CNAs). Besides mutations, these copy number changes are key characteristics of cancer …
(CNAs). Besides mutations, these copy number changes are key characteristics of cancer …
PandaOmics: an AI-driven platform for therapeutic target and biomarker discovery
PandaOmics is a cloud-based software platform that applies artificial intelligence and
bioinformatics techniques to multimodal omics and biomedical text data for therapeutic …
bioinformatics techniques to multimodal omics and biomedical text data for therapeutic …