Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

The yeast Saccharomyces cerevisiae has been a favorite organism for pioneering studies
on nutrient-sensing and signaling mechanisms. Many specific nutrient responses have been …

Cell size varies greatly between cell types, yet within a specific cell type and growth
condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size …

Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlap** …

Abstract TOR (T arget O f R apamycin) is a highly conserved protein kinase that is important
in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive …

The mammalian target of rapamycin (mTOR) is a central controller of cell growth and
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …

To understand regulatory systems, it would be useful to uniformly determine how different
components contribute to the expression of all other genes. We therefore monitored mRNA …

The target of rapamycin (TOR) signal-transduction pathway is an important mechanism by
which eucaryotic cells adjust their protein biosynthetic capacity to nutrient availability. Both …

The proteasome is essential for the selective degradation of most cellular proteins, but how
cells maintain adequate amounts of proteasome is unclear. Here we show that there is an …

Size is a fundamental attribute impacting cellular design, fitness, and function. Size
homeostasis requires a doubling of cell mass with each division. In yeast, division is delayed …