Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Nitric oxide (NO) methodology is a complex and often confusing science and the focus of
many debates and discussion concerning NO biochemistry. NO is involved in many …

Structural and functional complexities of the mammalian lung evolved to meet a unique set
of challenges, namely, the provision of efficient delivery of inspired air to all lung units within …

While complex physiological mechanisms exist to regulate and optimize tissue oxygenation
under various conditions, clinical and experimental evidence indicates that anaemia …

Well over 2 decades have passed since the endothelium-derived relaxation factor was
reported to be the gaseous molecule nitric oxide (NO). Although soluble guanylyl cyclase …

Recent studies have underscored questions about the balance of risk and benefit of RBC
transfusion. A better understanding of the nature and timing of molecular and functional …

Erythrocytes regulate vascular function through the modulation of oxygen delivery and the
scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell …

The free radical nitric oxide (NO•) exerts biological effects through the direct and reversible
interaction with specific targets (eg soluble guanylate cyclase) or through the generation of …

Nitric oxide participates in cellular signal transduction largely through S-nitrosylation of
allosteric and active-site cysteine thiols within proteins, forming S-nitroso-proteins (SNO …

Brown and brown-like beige/brite adipocytes dissipate energy and have been proposed as
therapeutic targets to combat metabolic disorders. However, the therapeutic effects of cell …