86 PFLOPS deep potential molecular dynamics simulation of 100 million atoms with ab initio accuracy

D Lu, H Wang, M Chen, L Lin, R Car, E Weinan… - Computer Physics …, 2021 - Elsevier
We present the GPU version of DeePMD-kit, which, upon training a deep neural network
model using ab initio data, can drive extremely large-scale molecular dynamics (MD) …

Molecular simulations of hydrophobic gating of pentameric ligand gated ion channels: insights into water and ions

S Rao, G Klesse, CI Lynch, SJ Tucker… - The Journal of …, 2021 - ACS Publications
Ion channels are proteins which form gated nanopores in biological membranes. Many
channels exhibit hydrophobic gating, whereby functional closure of a pore occurs by local …

LMFF: Efficient and scalable layered materials force field on heterogeneous many-core processors

P Gao, X Duan, J Guo, J Wang, Z Song, L Cui… - Proceedings of the …, 2021 - dl.acm.org
LAMMPS is one of the most popular Molecular Dynamic (MD) packages and is widely used
in the field of physics, chemistry and materials simulation. Layered Materials Force Field …

Distributed Heterogeneous Spiking Neural Network Simulator Using Sunway Accelerators

X Li, Z Wang, Y Pan, J Meng, S Feng… - Big Data Mining and …, 2024 - ieeexplore.ieee.org
Spiking Neural Network (SNN) simulation is very important for studying brain function and
validating the hypotheses for neuroscience, and it can also be used in artificial intelligence …

Cryo-EM structure and activator screening of human tryptophan hydroxylase 2

K Zhu, C Liu, Y Gao, J Lu, D Wang… - Frontiers in …, 2022 - frontiersin.org
Human tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the synthesis of
serotonin. Its dysfunction has been implicated in various psychiatric disorders such as …

Leveraging the Hardware Resources to Accelerate cryo-EM Reconstruction of RELION on the New Sunway Supercomputer

J Xu, J Fu, L Gan, Y Chen, Z Sun, Z Huang… - ACM Transactions on …, 2024 - dl.acm.org
The fast development of biomolecular structure determination has enabled the fine-grained
study of objects in the micro-world, such as proteins and RNAs. The world is benefited …

O2ath: An OpenMP offloading toolkit for the sunway heterogeneous manycore platform

H Lin, L Yan, Q Chang, H Lu, C Li, Q He, Z Song… - CCF Transactions on …, 2024 - Springer
The next generation Sunway supercomputer employs the SW26010pro processor, which
features a specialized on-chip heterogeneous architecture. Applications with significant …

Bio-esmd: A data centric implementation for large-scale biological system simulation on sunway taihulight supercomputer

X Duan, Q Shao, J Weng, B Schmidt… - … on Parallel and …, 2023 - ieeexplore.ieee.org
Molecular dynamics (MD) simulations of biological systems are playing an increasingly
important role in the research of pathogens and drugs. Most MD methods for biological …

Enabling AI-accelerated multiscale modeling of thrombogenesis at millisecond and molecular resolutions on supercomputers

Y Zhu, P Zhang, C Han, G Cong, Y Deng - … , Virtual Event, June 24–July 2 …, 2021 - Springer
We report the first congruent integration of HPC, AI, and multiscale modeling (MSM) for
solving a mainstream biomechanical problem of thrombogenesis involving 6 million …

FPGA-accelerated tersoff multi-body potential for molecular dynamics simulations

M Yuan, Q Liu, Q Deng, S **ang, L Gan, J Yang… - … Symposium on Applied …, 2022 - Springer
Molecular Dynamics simulation (MD) models the interactions of thousands to millions of
particles through the iterative application of fundamental physics, and MD is one of the core …