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[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …
Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses
that infect a wide range of avian and mammalian species, including humans. The …
that infect a wide range of avian and mammalian species, including humans. The …
Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion
Abstract Interleukin-33 (IL-33), an epithelial cell-derived cytokine that responds rapidly to
environmental insult, has a critical role in initiating airway inflammatory diseases. However …
environmental insult, has a critical role in initiating airway inflammatory diseases. However …
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral …
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …
[HTML][HTML] Functional evaluation of the P681H mutation on the proteolytic activation of the SARS-CoV-2 variant B. 1.1. 7 (Alpha) spike
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent causing the
COVID-19 pandemic. SARS-CoV-2 B. 1.1. 7 (Alpha), a WHO variant of concern first …
COVID-19 pandemic. SARS-CoV-2 B. 1.1. 7 (Alpha), a WHO variant of concern first …
A bioinformatic study of antimicrobial peptides identified in the Black Soldier Fly (BSF) Hermetia illucens (Diptera: Stratiomyidae)
Antimicrobial peptides (AMPs) play a key role in the innate immunity, the first line of defense
against bacteria, fungi, and viruses. AMPs are small molecules, ranging from 10 to 100 …
against bacteria, fungi, and viruses. AMPs are small molecules, ranging from 10 to 100 …
Proteolytic activation of SARS-CoV-2 spike at the S1/S2 boundary: potential role of proteases beyond furin
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S)
protein to mediate viral entry into host cells. Cleavage of the S protein at the S1/S2 and/or …
protein to mediate viral entry into host cells. Cleavage of the S protein at the S1/S2 and/or …
Improved prediction of signal peptides: SignalP 3.0
We describe improvements of the currently most popular method for prediction of classically
secreted proteins, SignalP. SignalP consists of two different predictors based on neural …
secreted proteins, SignalP. SignalP consists of two different predictors based on neural …
Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence
Post‐translational modifications (PTMs) occur on almost all proteins analyzed to date. The
function of a modified protein is often strongly affected by these modifications and therefore …
function of a modified protein is often strongly affected by these modifications and therefore …
Locating proteins in the cell using TargetP, SignalP and related tools
Determining the subcellular localization of a protein is an important first step toward
understanding its function. Here, we describe the properties of three well-known N-terminal …
understanding its function. Here, we describe the properties of three well-known N-terminal …