Cathepsins in the extracellular space: Focusing on non-lysosomal proteolytic functions with clinical implications
H Wang, A Inoue, Y Lei, H Wu, L Hong, XW Cheng - Cellular Signalling, 2023 - Elsevier
Cathepsins can be found in the extracellular space, cytoplasm, and nucleus. It was initially
suspected that the primary physiological function of the cathepsins was to break down …
suspected that the primary physiological function of the cathepsins was to break down …
Unveiling cytokine charge disparity as a potential mechanism for immune regulation
Cytokines are small signaling proteins that regulate the immune responses to infection and
tissue damage. Surface charges of cytokines determine their in vivo fate in immune …
tissue damage. Surface charges of cytokines determine their in vivo fate in immune …
[HTML][HTML] DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal …
AA Fitzgerald, S Wang, V Agarwal… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second
leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail to …
leading cause of cancer death in the USA by 2030. Immune checkpoint inhibitors fail to …
SLC7A11, a potential therapeutic target through induced ferroptosis in colon adenocarcinoma
X Cheng, Y Wang, L Liu, C Lv, C Liu… - Frontiers in Molecular …, 2022 - frontiersin.org
Background: Ferroptosis induced by SLC7A11 has an important translational value in the
treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon …
treatment of cancers. However, the mechanism of SLC7A11 in the pathogenesis of colon …
Inhibition of anti-tumor immunity by melanoma cell-derived Activin-A depends on STING
The transforming growth factor-β (TGF-β) family member activin A (hereafter Activin-A) is
overexpressed in many cancer types, often correlating with cancer-associated cachexia and …
overexpressed in many cancer types, often correlating with cancer-associated cachexia and …
ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer
G Wang, Y Romero, I Thevarajan… - OncoImmunology, 2023 - Taylor & Francis
Immunosuppressive tumor microenvironment (TME) impedes anti-tumor immune responses
and contributes to immunotherapy resistance in triple-negative breast cancer (TNBC) …
and contributes to immunotherapy resistance in triple-negative breast cancer (TNBC) …
The chemokine CXCL7 is related to angiogenesis and associated with poor prognosis in colorectal cancer patients
L Li, K Jiang, D Li, D Li, Z Fan, G Dai, S Tu, X Liu… - Frontiers in …, 2021 - frontiersin.org
Objective The present study was designed to investigate the role of the chemokine CXCL7
in angiogenesis and explore its prognostic value in colorectal cancer (CRC). Methods A total …
in angiogenesis and explore its prognostic value in colorectal cancer (CRC). Methods A total …
The role of post-translational modifications of chemokines by CD26 in cancer
A De Zutter, J Van Damme, S Struyf - Cancers, 2021 - mdpi.com
Simple Summary Chemokines are central players in cancer and can be post-translationally
modified by dipeptidyl peptidase IV (DPPIV)/CD26. This can have different effects on …
modified by dipeptidyl peptidase IV (DPPIV)/CD26. This can have different effects on …
Amplification of the CXCR3/CXCL9 axis via intratumoral electroporation of plasmid CXCL9 synergizes with plasmid IL-12 therapy to elicit robust anti-tumor immunity
Clinical studies have demonstrated that local expression of the cytokine IL-12 drives
interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately …
interferon-gamma expression and recruits T cells to the tumor microenvironment, ultimately …
SLC7A11, a potential immunotherapeutic target in lung adenocarcinoma
Q Shan, C Zhang, Y Li, Q Li, Y Zhang, X Li, J Shi… - Scientific Reports, 2023 - nature.com
SLC7A11 has significant translational value in cancer treatment. However, there are few
studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD) …
studies on whether SLC7A11 affects the immune status of lung adenocarcinoma (LUAD) …