Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Neurodegenerative diseases are a group of pathological conditions that cause motor
incordination (jerking movements), cognitive and memory impairments result from …

Mitochondria play a critical role in energy production, cell signalling and cell survival.
Defects in mitochondrial function contribute to the ageing process and ageing-related …

Sirtuins, which are NAD+-dependent class III histone deacetylases, are involved in various
biological processes, including DNA damage repair, immune inflammation, oxidative stress …

Histone deacetylases (HDAC s) represent emerging therapeutic targets in the context of
neurodegeneration. Indeed, pharmacologic inhibition of HDAC s activity in the nervous …

Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an
NAD+-dependent manner. The mammalian family of sirtuins is composed of seven histone …

Stroke is a major cause of mortality and disability globally, with ischemic stroke (IS)
accounting for over 80% of all stroke cases. The pathological process of IS involves …

Many populations worldwide are suffering from central nervous system (CNS) diseases such
as brain tumors, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease …

As cellular metabolic hubs, mitochondria are the main energy producers for the cell. These
organelles host essential energy producing biochemical processes, including the TCA cycle …

Silent information regulators, sirtuins (SIRTs), are a family of enzymes which take part in
major posttranslational modifications of proteins and contribute to multiple cellular …