In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

Since the serendipitous discovery of the biological activity of cisplatin, 1 the drug has been
applied extensively in cancer chemotherapy. 2 Platinum-based drugs such as cisplatin …

Not only the 24 or so essential elements, but also nonessential and even radioactive
elements have enormous potential for applications in medicine. In the fight against cancer …

THE success of cisplatin in cancer chemotherapy derives from its ability to crosslink DNA
and alter the structure. Most cisplatiná¤-DNA adducts are intrastrand d (GpG) and d (ApG) …

Abstract Cisplatin [cis-DDP, cis-diamminedichloroplatinum (II)] is a potent anticancer drug
that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary …

Cisplatin, a DNA-damaging agent, is one of the most widely used anticancer drugs. As with
all members of this class of chemotherapeutic compounds, the clinical success of cisplatin is …

Publisher Summary This chapter summarizes recent information on the function of high-
mobility-group (HMG) proteins. Advances in this field were made primarily by elucidating the …

The cytotoxicity of platinum compounds is thought to be determined primarily by their DNA
adducts. Cisplatin and oxaliplatin are structurally distinct, but form the same types of adducts …

Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA
and forms 1, 2-d (ApG), 1, 2-d (GpG) and 1, 3-d (GpTpG) intrastrand crosslinks, interstrand …

The X-ray crystal structure of d (CCTCTG* G* TCTCC)⊙ d (GGAGACCAGAGG), where G*
G* represents the major adduct of the antitumor drug cisplatin on a duplex DNA dodecamer …