Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
Bacterial type IV secretion systems (T4SSs) are a functionally diverse translocation
superfamily. They consist mainly of two large subfamilies:(i) conjugation systems that …

Aim, load, fire: the type VI secretion system, a bacterial nanoweapon

FR Cianfanelli, L Monlezun, SJ Coulthurst - Trends in microbiology, 2016 - cell.com
Bacteria utilise specialised protein secretion systems to interact with host organisms,
competitor bacteria, and the environment. The Type VI secretion system (T6SS) is a versatile …

The Type VI secretion system: a versatile bacterial weapon

S Coulthurst - Microbiology, 2019 - microbiologyresearch.org
The Type VI secretion system (T6SS) is a protein nanomachine that is widespread in Gram-
negative bacteria and is used to translocate effector proteins directly into neighbouring cells …

Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut

TG Sana, N Flaugnatti, KA Lugo… - Proceedings of the …, 2016 - National Acad Sciences
The mammalian gastrointestinal tract is colonized by a high-density polymicrobial
community where bacteria compete for niches and resources. One key competition strategy …

Protein-injection machines in bacteria

JE Galán, G Waksman - Cell, 2018 - cell.com
Many bacteria have evolved specialized nanomachines with the remarkable ability to inject
multiple bacterially encoded effector proteins into eukaryotic or prokaryotic cells. Known as …

The Pseudomonas putida T6SS is a plant warden against phytopathogens

P Bernal, LP Allsopp, A Filloux, MA Llamas - The ISME journal, 2017 - academic.oup.com
Bacterial type VI secretion systems (T6SSs) are molecular weapons designed to deliver
toxic effectors into prey cells. These nanomachines have an important role in inter-bacterial …

An overview of anti-eukaryotic T6SS effectors

J Monjarás Feria, MA Valvano - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
The type VI secretion system (T6SS) is a transmembrane multiprotein nanomachine
employed by many Gram-negative bacterial species to translocate, in a contact-dependent …

Type VI secretion and anti-host effectors

A Hachani, TE Wood, A Filloux - Current opinion in microbiology, 2016 - Elsevier
Highlights•T6SS is a secretion system involved in the virulence of bacterial pathogens.•This
versatile weapon can target both prokaryotic and eukaryotic cells.•The T6SS tail/spike …

Type VI Secretion System in Pathogenic Escherichia coli: Structure, Role in Virulence, and Acquisition

F Navarro-Garcia, F Ruiz-Perez, Á Cataldi… - Frontiers in …, 2019 - frontiersin.org
Bacterial pathogens utilize a myriad of mechanisms to invade mammalian hosts, damage
tissue sites, and evade the immune system. One essential strategy of Gram-negative …

Cell-wall recycling of the gram-negative bacteria and the nexus to antibiotic resistance

DA Dik, JF Fisher, S Mobashery - Chemical reviews, 2018 - ACS Publications
The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …