During the past several decades, numerous studies have provided insights into biological
characteristics of cancer cells and identified various hallmarks of cancer acquired in the …

DNA integrity is constantly challenged by endogenous and exogenous factors that can alter
the DNA sequence, leading to mutagenesis, aberrant transcriptional activity, and cytotoxicity …

Poly (ADP-ribose) polymerase (PARP) inhibitors are increasingly being studied as cancer
drugs, as single agents, or as a part of combination therapies. Imaging of PARP using a …

Molecular radiotherapy using 177Lu-DOTATATE is a most effective treatment for
somatostatin receptor–expressing neuroendocrine tumors. Despite its frequent and …

Rationale: An effective absorbed dose response relationship is yet to be established for
Lutetium-177 based radionuclide therapies such as 177Lu-DOTATATE and 177Lu-PSMA …

Neoadjuvant therapy is routinely used in pancreatic ductal adenocarcinoma (PDAC), but not
all tumors respond to this treatment. Current clinical imaging techniques are not able to …

The genetic code to life is balanced on a string of DNA that is under constant metabolic and
physical stress from environmental forces. Nearly all diseases have a genetic component …

Successful treatment of cancer patients requires balancing of the dose, timing, and type of
therapeutic regimen. Detection of increased cell death may serve as a predictor of the …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial disorder of the respiratory system
that can be debilitating as it progresses and has experienced a slow rise in incidence in past …

Cell death plays a prominent role in the treatment of cancer, because most anticancer
therapies act by the induction of cell death including apoptosis, necrosis, and other …