The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of
enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most …

CD38 is a multifunctional protein widely expressed in cells from the immune system and as
a soluble form in biological fluids. CD38 expression is up-regulated by an array of …

Despite the clinical success of anti-CD20 monoclonal antibody (mAb) in the treatment of
lymphoma, there remains considerable uncertainty about its mechanism of action. Here we …

Despite the success of anti-CD20 monoclonal antibody (mAb) in the treatment of lymphoma,
there remains considerable uncertainty about their mechanism (s) of action. Here, we show …

Daratumumab is a human monoclonal antibody that targets CD38, a cell surface protein that
is overexpressed on multiple myeloma (MM) cells. Preclinical studies have shown that …

Human CD38 is the mammalian prototype of a family of proteins which share structural
similarities and an ectoenzymatic activity involved in the production of calcium mobilizing …

The human CD38 antigen, originally described by Reinherz et al. 1 as T10, is a 46 kDa type
1I transmembrane glycoproteia with a short N-terminal cytoplasmic tail and monomorphic …

B lymphocytes must respond to low concentrations of antigen despite having low affinity
antigen receptors during the primary immune response. CD19, a B cell-restricted membrane …

Human CD38 is a nonlineage‐re‐stricted type II transmembrane glycoprotein that has
emerged as a multifunctional protein in recent years. It can serve as an ectoenzyme that …

Rituximab is routinely used for the treatment of neoplasia, although the mechanism of action
remains uncertain. In the current study, CD20-induced apoptosis was investigated with a …