[HTML][HTML] Sleep homeostasis and the circadian clock: do the circadian pacemaker and the sleep homeostat influence each other's functioning?
T Deboer - Neurobiology of sleep and circadian rhythms, 2018 - Elsevier
Sleep is regulated by a homeostatic and a circadian process. Together these two processes
determine most aspects of sleep and related variables like sleepiness and alertness. The …
determine most aspects of sleep and related variables like sleepiness and alertness. The …
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
PL Lowrey, JS Takahashi - Annu. Rev. Genomics Hum. Genet., 2004 - annualreviews.org
▪ Abstract During the past decade, the molecular mechanisms underlying the mammalian
circadian clock have been defined. A core set of circadian clock genes common to most cells …
circadian clock have been defined. A core set of circadian clock genes common to most cells …
RNA-methylation-dependent RNA processing controls the speed of the circadian clock
The eukaryotic biological clock involves a negative transcription-translation feedback loop in
which clock genes regulate their own transcription and that of output genes of metabolic …
which clock genes regulate their own transcription and that of output genes of metabolic …
PERIOD2:: LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Mammalian circadian rhythms are regulated by the suprachiasmatic nucleus (SCN), and
current dogma holds that the SCN is required for the expression of circadian rhythms in …
current dogma holds that the SCN is required for the expression of circadian rhythms in …
[HTML][HTML] The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here
that mice deficient in the mPer2 gene are cancer prone. After γ radiation, these mice show a …
that mice deficient in the mPer2 gene are cancer prone. After γ radiation, these mice show a …
Role of transposable elements in heterochromatin and epigenetic control
Heterochromatin has been defined as deeply staining chromosomal material that remains
condensed in interphase, whereas euchromatin undergoes de-condensation …
condensed in interphase, whereas euchromatin undergoes de-condensation …
Synchronization of cellular clocks in the suprachiasmatic nucleus
Individual cellular clocks in the suprachiasmatic nucleus (SCN), the circadian center, are
integrated into a stable and robust pacemaker with a period length of about 24 hours. We …
integrated into a stable and robust pacemaker with a period length of about 24 hours. We …
Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors
Circadian rhythms result from feedback loops involving clock genes and their protein
products. In mammals, 2 orphan nuclear receptors, REV-ERBα and RORα, play important …
products. In mammals, 2 orphan nuclear receptors, REV-ERBα and RORα, play important …
Post-translational modifications regulate the ticking of the circadian clock
Getting a good night's sleep is on everyone's to-do list. So is, no doubt, staying awake during
late afternoon seminars. Our internal clocks control these and many more workings of the …
late afternoon seminars. Our internal clocks control these and many more workings of the …
Light activates the adrenal gland: timing of gene expression and glucocorticoid release
A Ishida, T Mutoh, T Ueyama, H Bando, S Masubuchi… - Cell metabolism, 2005 - cell.com
Light is a powerful synchronizer of the circadian rhythms, and bright light therapy is known to
improve metabolic and hormonal status of circadian rhythm sleep disorders, although its …
improve metabolic and hormonal status of circadian rhythm sleep disorders, although its …