Targeting P21-activated kinase-1 for metastatic prostate cancer
Simple Summary Metastatic prostate cancer (mPCa) results in high mortality and there are
no effective treatments. The molecular mechanisms mediating the transition of early-stage …
no effective treatments. The molecular mechanisms mediating the transition of early-stage …
p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond
X Li, F Li - Cancers, 2022 - mdpi.com
Simple Summary Gastrointestinal tumors are the most common tumors with a high mortality
rate worldwide. Numerous protein kinases have been studied in anticipation of finding …
rate worldwide. Numerous protein kinases have been studied in anticipation of finding …
Oncogenic potential of PIK3CD in glioblastoma is exerted through cytoskeletal proteins PAK3 and PLEK2
The Class IA phosphoinositide-3-kinase catalytic isoforms p110α, p110β, and p110δ have
been implicated to play vital but overlap** roles in various cancers, including glioblastoma …
been implicated to play vital but overlap** roles in various cancers, including glioblastoma …
Aqueous and ethanolic extracts of Moringa oleifera leaves induce selective cytotoxicity in Raji and Jurkat cell lines by activating the P21 pathway independent of P53
L Rajabi, M Ebrahimdoost, SA Mohammadi… - Molecular Biology …, 2025 - Springer
Background The traditional use of Moringa oleifera (MO), an essential food source in Africa
and Asia, to cure various diseases dates back thousands of years. This study examines the …
and Asia, to cure various diseases dates back thousands of years. This study examines the …
PAK1 copy number in breast cancer—Associations with proliferation and molecular subtypes
AH Skjervold, M Valla, B Ytterhus, AM Bofin - PloS one, 2023 - journals.plos.org
Introduction P21-activated kinase 1 (PAK1) is known to be overexpressed in several human
tumour types, including breast cancer (BC). It is located on chromosome 11 (11q13. 5-q14 …
tumour types, including breast cancer (BC). It is located on chromosome 11 (11q13. 5-q14 …
P21-activated kinase-1 signaling is required to preserve adipose tissue homeostasis and cardiac function
Abstract While P21-activated kinase-1 (PAK1) has been extensively studied in relation to
cardiovascular health and glucose metabolism, its roles within adipose tissue and …
cardiovascular health and glucose metabolism, its roles within adipose tissue and …
Exploring RHOGTPases: a computational study of protein-protein interactions and drug design
MA La Serra - 2024 - amsdottorato.unibo.it
The CDC42 RHOGTPases subfamily (RHOJ, RHOQ, CDC42) is often overexpressed but
rarely mutated in cancer. These GTPases play a critical role in governing both the …
rarely mutated in cancer. These GTPases play a critical role in governing both the …
Effect of SARAF-based peptides on the store-operated calcium entry and cell invasion in triple-negative breast cancer model
MP Saldías Maulén - 2023 - repositorio.uchile.cl
Breast cancer is the most common cause of death among women. While there have been
significant improvements in diagnosis and treatment, the spread of cancer to other areas of …
significant improvements in diagnosis and treatment, the spread of cancer to other areas of …