Mesenchymal stem/stromal cell senescence: hallmarks, mechanisms, and combating strategies

Z Weng, Y Wang, T Ouchi, H Liu, X Qiao… - Stem Cells …, 2022 - academic.oup.com
Aging is a multifaceted and complicated process, manifested by a decline of normal
physiological functions across tissues and organs, leading to overt frailty, mortality, and …

Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing

H Lin, J Sohn, H Shen, MT Langhans, RS Tuan - Biomaterials, 2019 - Elsevier
Bone has well documented natural healing capacity that normally is sufficient to repair
fractures and other common injuries. However, the properties of bone change throughout …

Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies

J Liu, Y Ding, Z Liu, X Liang - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are multipotent cells capable of self-renewal and
differentiation. There is increasing evidence of the therapeutic value of MSCs in various …

Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy

V Turinetto, E Vitale, C Giachino - International journal of molecular …, 2016 - mdpi.com
Regenerative medicine is extensively interested in develo** cell therapies using
mesenchymal stem cells (MSCs), with applications to several aging-associated diseases …

Autophagy in bone remodeling: a regulator of oxidative stress

C Zhu, S Shen, S Zhang, M Huang, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Bone homeostasis involves bone formation and bone resorption, which are processes that
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …

Biomaterials based strategies for skeletal muscle tissue engineering: existing technologies and future trends

TH Qazi, DJ Mooney, M Pumberger, S Geissler… - Biomaterials, 2015 - Elsevier
Skeletal muscles have a robust capacity to regenerate, but under compromised conditions,
such as severe trauma, the loss of muscle functionality is inevitable. Research carried out in …

Mitochondrial dynamics: fission and fusion in fate determination of mesenchymal stem cells

L Ren, X Chen, X Chen, J Li, B Cheng… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Mitochondrial transfer and regulators of mesenchymal stromal cell function and therapeutic efficacy

A Mohammadalipour, SP Dumbali… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding
microenvironment in both normal physiology and pathological conditions. While MSCs …

The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells

Q Li, Z Gao, Y Chen, MX Guan - Protein & cell, 2017 - Springer
Mesenchymal stem cells (MSCs) are progenitors of connective tissues, which have emerged
as important tools for tissue engineering due to their differentiation potential along various …

Age-related changes in bone marrow mesenchymal stromal cells: a potential impact on osteoporosis and osteoarthritis development

P Ganguly, JJ El-Jawhari, PV Giannoudis… - Cell …, 2017 - journals.sagepub.com
Aging at the cellular level is a complex process resulting from accumulation of various
damages leading to functional impairment and a reduced quality of life at the level of the …