Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy

AJ Marian, E Braunwald - Circulation research, 2017 - Am Heart Assoc
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

MicroRNAs in cardiac diseases

RMW Colpaert, M Calore - Cells, 2019 - mdpi.com
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …

Inhibition of miR-25 improves cardiac contractility in the failing heart

C Wahlquist, D Jeong, A Rojas-Muñoz, C Kho, A Lee… - Nature, 2014 - nature.com
Heart failure is characterized by a debilitating decline in cardiac function, and recent clinical
trial results indicate that improving the contractility of heart muscle cells by boosting …

Reverse cardio‐oncology: cancer development in patients with cardiovascular disease

JP Aboumsallem, J Moslehi… - Journal of the American …, 2020 - Am Heart Assoc
Overwhelming epidemiological evidence demonstrate that cardiovascular disease and
cancer represent major health burdens in the United States, and they are the leading causes …

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

KM Akat, DV Moore-McGriff… - Proceedings of the …, 2014 - National Acad Sciences
Heart failure (HF) is associated with high morbidity and mortality and its incidence is
increasing worldwide. MicroRNAs (miRNAs) are potential markers and targets for diagnostic …

[HTML][HTML] MicroRNAs as important regulators of exercise adaptation

GJJ Silva, A Bye, H El Azzouzi, U Wisløff - Progress in cardiovascular …, 2017 - Elsevier
A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …

MicroRNAs in cancer and cardiovascular disease

M Ilieva, R Panella, S Uchida - Cells, 2022 - mdpi.com
Although cardiac tumor formation is rare, accumulating evidence suggests that the two
leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of …

Novel biomarkers of heart failure

A Savic-Radojevic, M Pljesa-Ercegovac, M Matic… - Advances in clinical …, 2017 - Elsevier
Although substantial improvements have been made in majority of cardiac disorders, heart
failure (HF) remains a major health problem, with both increasing incidence and prevalence …

The hypoxia-inducible microRNA cluster miR-199a∼ 214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation

H El Azzouzi, S Leptidis, E Dirkx, J Hoeks, B van Bree… - Cell metabolism, 2013 - cell.com
Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy
metabolism in the heart. Here, we propose a mechanism that integrates two deleterious …

Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis

G Morciano, A Rimessi, S Patergnani, VAM Vitto… - Pharmacological …, 2022 - Elsevier
Intracellular calcium signaling is a universal language source shared by the most part of
biological entities inside cells that, all together, give rise to physiological and functional …