Hypertrophic cardiomyopathy: genetics, pathogenesis, clinical manifestations, diagnosis, and therapy
AJ Marian, E Braunwald - Circulation research, 2017 - Am Heart Assoc
Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …
MicroRNAs in cardiac diseases
RMW Colpaert, M Calore - Cells, 2019 - mdpi.com
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional
regulation of gene expression in major cardiac physiological and pathological processes …
regulation of gene expression in major cardiac physiological and pathological processes …
Inhibition of miR-25 improves cardiac contractility in the failing heart
Heart failure is characterized by a debilitating decline in cardiac function, and recent clinical
trial results indicate that improving the contractility of heart muscle cells by boosting …
trial results indicate that improving the contractility of heart muscle cells by boosting …
Reverse cardio‐oncology: cancer development in patients with cardiovascular disease
Overwhelming epidemiological evidence demonstrate that cardiovascular disease and
cancer represent major health burdens in the United States, and they are the leading causes …
cancer represent major health burdens in the United States, and they are the leading causes …
Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers
KM Akat, DV Moore-McGriff… - Proceedings of the …, 2014 - National Acad Sciences
Heart failure (HF) is associated with high morbidity and mortality and its incidence is
increasing worldwide. MicroRNAs (miRNAs) are potential markers and targets for diagnostic …
increasing worldwide. MicroRNAs (miRNAs) are potential markers and targets for diagnostic …
[HTML][HTML] MicroRNAs as important regulators of exercise adaptation
A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …
MicroRNAs in cancer and cardiovascular disease
Although cardiac tumor formation is rare, accumulating evidence suggests that the two
leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of …
leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of …
Novel biomarkers of heart failure
A Savic-Radojevic, M Pljesa-Ercegovac, M Matic… - Advances in clinical …, 2017 - Elsevier
Although substantial improvements have been made in majority of cardiac disorders, heart
failure (HF) remains a major health problem, with both increasing incidence and prevalence …
failure (HF) remains a major health problem, with both increasing incidence and prevalence …
The hypoxia-inducible microRNA cluster miR-199a∼ 214 targets myocardial PPARδ and impairs mitochondrial fatty acid oxidation
H El Azzouzi, S Leptidis, E Dirkx, J Hoeks, B van Bree… - Cell metabolism, 2013 - cell.com
Peroxisome proliferator-activated receptor δ (PPARδ) is a critical regulator of energy
metabolism in the heart. Here, we propose a mechanism that integrates two deleterious …
metabolism in the heart. Here, we propose a mechanism that integrates two deleterious …
Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis
Intracellular calcium signaling is a universal language source shared by the most part of
biological entities inside cells that, all together, give rise to physiological and functional …
biological entities inside cells that, all together, give rise to physiological and functional …