Adenovirus and adeno-associated virus vectors
CM Lai, YKY Lai, PE Rakoczy - DNA and cell biology, 2002 - liebertpub.com
Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among
the most extensively used vectors in gene therapy studies to date. These two vectors share …
the most extensively used vectors in gene therapy studies to date. These two vectors share …
Development of nonhuman adenoviruses as vaccine vectors
Human adenoviral (HAd) vectors have demonstrated great potential as vaccine vectors.
Preclinical and clinical studies have demonstrated the feasibility of vector design, robust …
Preclinical and clinical studies have demonstrated the feasibility of vector design, robust …
Mucosal delivery of vaccines in domestic animals
Mucosal vaccination is proving to be one of the greatest challenges in modern vaccine
development. Although highly beneficial for achieving protective immunity, the induction of …
development. Although highly beneficial for achieving protective immunity, the induction of …
Use of adenoviral vectors as veterinary vaccines
Vaccines are the most effective and inexpensive prophylactic tool in veterinary medicine.
Ideally, vaccines should induce a lifelong protective immunity against the target pathogen …
Ideally, vaccines should induce a lifelong protective immunity against the target pathogen …
Immunization of cattle with recombinant Newcastle disease virus expressing bovine herpesvirus-1 (BHV-1) glycoprotein D induces mucosal and serum antibody …
Bovine herpesvirus-1 (BHV-1) is a major cause of respiratory tract diseases in cattle.
Vaccination of cattle against BHV-1 is a high priority. A major concern of currently modified …
Vaccination of cattle against BHV-1 is a high priority. A major concern of currently modified …
Use of animal models in the development of human vaccines
V Gerdts, SD Littel-van den Hurk, PJ Griebel… - Future …, 2007 - Taylor & Francis
Over the past 100 years, animal infectious disease research has played a crucial role in the
development of human vaccines. In fact, many of today's vaccines are based on utilizing …
development of human vaccines. In fact, many of today's vaccines are based on utilizing …
A new look at vaccine strategies against PPRV focused on adenoviral candidates
Peste des petits ruminants virus (PPRV) is a virus that mainly infects goats and sheep
causing significant economic loss in Africa and Asia, but also posing a serious threat to …
causing significant economic loss in Africa and Asia, but also posing a serious threat to …
Adenovirus hexon T-cell epitope is recognized by most adults and is restricted by HLA DP4, the most common class II allele
J Tang, M Olive, K Champagne, N Flomenberg… - Gene therapy, 2004 - nature.com
The immunogenicity of adenovirus (Ad) vectors is enhanced by virus-specific memory
immune responses present in most individuals as a result of past exposure to these …
immune responses present in most individuals as a result of past exposure to these …
Induction of protective immunity to bovine herpesvirus type 1 in cattle by intranasal administration of replication-defective human adenovirus type 5 expressing …
S Gogev, N Vanderheijden, M Lemaire, F Schynts… - Vaccine, 2002 - Elsevier
Replication-defective human adenoviruses type 5 (HAd5) expressing the bovine
herpesvirus type 1 (BHV-1) glycoprotein gC or gD under the control of the human …
herpesvirus type 1 (BHV-1) glycoprotein gC or gD under the control of the human …
Glycol chitosan improves the efficacy of intranasally administrated replication defective human adenovirus type 5 expressing glycoprotein D of bovine herpesvirus 1
S Gogev, K de Fays, MF Versali, S Gautier, E Thiry - Vaccine, 2004 - Elsevier
The ability of two soluble formulations, namely chitosan and glycol chitosan, when used as
an intranasal adjuvant, to improve the immunogenicity of an intranasal human adenovirus …
an intranasal adjuvant, to improve the immunogenicity of an intranasal human adenovirus …