The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …

The renin-angiotensin system (RAS) has a pivotal role in the maintenance of extracellular
volume homeostasis and blood pressure through complex mechanisms. Apart from the well …

The complexity of the intrarenal renin-angiotensin (Ang) system (RAS) continues to reveal
itself as evidence accumulates demonstrating its robust independent regulation in the …

Activation of the intrarenal renin-angiotensin system (RAS) can elicit hypertension
independently from the systemic RAS. However, the precise mechanisms by which …

The intrarenal renin–angiotensin system is critical for the regulation of tubule sodium
reabsorption, renal haemodynamics and blood pressure. The excretion of renin in urine can …

Renin synthesis and secretion by principal cells of the collecting duct are enhanced in
angiotensin (Ang) II–dependent hypertension. The presence of renin/(pro) renin and its …

Angiotensin (Ang) II plays a critical role in cardiovascular and blood pressure regulation.
Ang II is produced by angiotensin‐converting enzyme (ACE) and it interacts with the Ang AT …

Rationale: Cleavage of the extracellular domain of the PRR ([pro] renin receptor) yields a
soluble fragment (sPRR). Although changes in plasma sPRR levels have been reported in …

Patients and animals with renal injury exhibit increased urinary excretion of
angiotensinogen. Although increased tubular synthesis of angiotensinogen contributes to …

Kidneys continuously filter an enormous amount of sodium and adapt kidney Na+
reabsorption to match Na+ intake to maintain circulatory volume and electrolyte …