Review of bilayer tablet technology

A Abebe, I Akseli, O Sprockel, N Kottala… - International journal of …, 2014 - Elsevier
Therapeutic strategies based on oral delivery of bilayer (and multilayer) tablets are gaining
more acceptance among brand and generic products due to a confluence of factors …

Fast time-resolved micro-CT imaging of pharmaceutical tablets: Insights into water uptake and disintegration

S Ferdoush, SB Kzam, PHC Martins… - International journal of …, 2023 - Elsevier
We use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to
visualize water penetration through the porous network of immediate-release …

[HTML][HTML] A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders

LH Han, JA Elliott, AC Bentham, A Mills… - International Journal of …, 2008 - Elsevier
In this paper, we present a modified density-dependent Drucker-Prager Cap (DPC) model to
simulate the compaction behaviour of pharmaceutical powders. In particular, a nonlinear …

Performance appraisal of Trichoderma viride based novel tablet and powder formulations for management of Fusarium wilt disease in chickpea

PC Pradhan, A Mukhopadhyay, R Kumar… - Frontiers in Plant …, 2022 - frontiersin.org
In develo** a Trichoderma viride-based biocontrol program for Fusarium wilt disease in
chickpea, the choice of the quality formulation is imperative. In the present study, two types …

Itraconazole amorphous solid dispersion tablets: formulation and compaction process optimization using quality by design principles and tools

H Triboandas, K Pitt, M Bezerra, D Ach-Hubert… - Pharmaceutics, 2022 - mdpi.com
BCS Class II drugs, such as itraconazole (ITZ), exhibit poor solubility (1–4 ng/mL) and so
require solubility enhancement. Therefore, ITZ and Kollidon® VA64 (KOL) amorphous solid …

[HTML][HTML] Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying

BV Schönfeld, U Westedt, KG Wagner - International Journal of …, 2021 - Elsevier
The present study explored vacuum drum drying (VDD) as an alternative technology for
amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) …

Fast and non-destructive pore structure analysis using terahertz time-domain spectroscopy

D Markl, P Bawuah, C Ridgway, S van den Ban… - International Journal of …, 2018 - Elsevier
Pharmaceutical tablets are typically manufactured by the uni-axial compaction of powder
that is confined radially by a rigid die. The directional nature of the compaction process …

Lamination of biconvex tablets: Numerical and experimental study

V Mazel, H Diarra, J Malvestio, P Tchoreloff - International Journal of …, 2018 - Elsevier
Cap** and lamination are common industrial problems during the manufacturing of
pharmaceutical tablets. Even if they are commonly treated together, these phenomena …

Non-destructive determination of anisotropic mechanical properties of pharmaceutical solid dosage forms

I Akseli, BC Hancock, C Cetinkaya - International journal of pharmaceutics, 2009 - Elsevier
The mechanical property anisotropy of compacts made from four commercially available
pharmaceutical excipient powders (microcrystalline cellulose, lactose monohydrate …

Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices

AL Ching, CV Liew, LW Chan, PWS Heng - European journal of …, 2008 - Elsevier
Lamination of alginate matrix tablet at acidic pH can compromise its function as a sustained
release carrier. This phenomenon is associated with the conversion of sodium alginate to …