The pyrazolone structural motif is a critical element of drugs aimed at different biological end-
points. Medicinal chemistry researches have synthesized drug-like pyrazolone candidates …

Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

Searching for effective and selective anti‐inflammatory agents, our study involved designing
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …

Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …

Transient receptor potential vanilloid 1 (TRPV1) channels are widely distributed in sensory
nerve endings, the central nervous system, and other tissues, functioning as ion channel …

Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

Novel differently substituted pyrazole derivatives were designed, synthesized and evaluated
for their anticancer activity. All compounds selectively inhibited COX-2 enzyme (IC 50 …

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

Diabetes mellitus is a multi-systematic chronic metabolic disorder and life-threatening
disease resulting from impaired glucose homeostasis. The inhibition of glucosidase …

The cardiovascular side effects associated with COX-2 selective drugs were the worst for
coxibs leading to their withdrawal from the market a few years after their discovery …