Covering: 2000 to 2019 According to a 2012 survey from the Centers for Disease Control
and Prevention, approximately 18% of the US population uses natural products (including …

Natural product research aims to characterize specialized metabolites from various living
organisms and assess their biological properties from either a chemical ecology or drug …

It is a common problem in natural product therapeutic lead discovery programs that despite
good bioassay results in the initial extract, the active compound (s) may not be isolated …

Covering: up to 2019 Landmark advances in bioinformatics tools have recently enhanced
the field of natural products research, putting today's natural product chemists in the …

The genomes of filamentous fungi contain up to 90 biosynthetic gene clusters (BGCs)
encoding diverse secondary metabolites—an enormous reservoir of untapped chemical …

Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Herbal medicine (HM) has made a major contribution to the drug discovery process with
regard to identifying products compounds. Currently, more attention has been focused on …

Covering: 2000 to 2019 Natural products (NPs) are important sources of human therapeutic
agents and pesticides. To prevent self-harm from bioactive NPs, some microbial producers …

A combined strategy of building blocks recognition and molecular network construction,
termed the building blocks‐based molecular network (BBMN), was first presented to …

Highlights•Most BGCs are silent due to their tight regulation under conventional laboratory
culture conditions.•New methods have been developed to activate silent BGCs in both …