The relationship between diabetes mellitus and cancers and its underlying mechanisms

B Zhu, S Qu - Frontiers in Endocrinology, 2022 - frontiersin.org
Epidemiological studies suggest associations between diabetes mellitus and some cancers.
The risk of a number of cancers appears to be increased in diabetes mellitus. On the other …

Pharmacotherapy of obesity: available medications and drugs under investigation

E Pilitsi, OM Farr, SA Polyzos, N Perakakis… - Metabolism, 2019 - Elsevier
Obesity is a chronic disease with a continuously rising prevalence that currently affects more
than half a billion people worldwide. Energy balance and appetite are highly regulated via …

Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells

YS Lee, HS Jun - Metabolism, 2014 - Elsevier
Abstract Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-
cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin …

Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon …

AE Butler, M Campbell-Thompson, T Gurlo… - Diabetes, 2013 - diabetesjournals.org
Controversy exists regarding the potential regenerative influences of incretin therapy on
pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of …

Glucagonlike peptide 1–based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study

S Singh, HY Chang, TM Richards… - JAMA internal …, 2013 - jamanetwork.com
Importance Acute pancreatitis has significant morbidity and mortality. Previous studies have
raised the possibility that glucagonlike peptide 1 (GLP-1)–based therapies, including a GLP …

Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies

L Li, J Shen, MM Bala, JW Busse, S Ebrahim… - Bmj, 2014 - bmj.com
Objective To investigate the risk of pancreatitis associated with the use of incretin-based
treatments in patients with type 2 diabetes mellitus. Design Systematic review and meta …

A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?

PC Butler, M Elashoff, R Elashoff, EAM Gale - Diabetes care, 2013 - diabetesjournals.org
There is no question that incretin-based glucose-lowering medications have proven to be
effective glucose-lowering agents. Glucagon-like peptide 1 (GLP-1) receptor agonists …

The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer's diseases

M Alrouji, HM Al-Kuraishy, AI Al-Gareeb… - Diabetology & Metabolic …, 2023 - Springer
Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans
has different physiological functions including inhibiting the release of insulin and glucagon …

Pancreatogenic diabetes: special considerations for management

YF Cui, DK Andersen - Pancreatology, 2011 - karger.com
Abstract Background/Aims: Pancreatogenic, or type 3c, diabetes (T3cDM) occurs due to
inherited or acquired pancreatic disease or resection. Although similar to the more prevalent …

Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls

DJ Drucker - Diabetes, 2013 - diabetesjournals.org
Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
are incretin hormones that control the secretion of insulin, glucagon, and somatostatin to …