Antigen-presenting dendritic cells often acquire foreign antigens in peripheral tissues such
as the skin. Optimal encounter with naive T cells for the presentation of these antigens …

The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

Numerous reports document the role of vascular adhesion molecules in the development
and progression of atherosclerosis. Recent novel findings in the field of adhesion molecules …

The gut mucosa is constantly challenged by a bombardment of foreign antigens and
environmental microorganisms. As such, the precise regulation of the intestinal barrier …

Intercellular junctions mediate adhesion and communication between adjoining cells.
Although formed by different molecules, tight junctions (TJs) and adherens junctions (AJs) …

Migration of leukocytes from the skin to lymph nodes (LNs) via afferent lymphatic vessels
(LVs) is pivotal for adaptive immune responses,. Circadian rhythms have emerged as …

Background & Aims There is evidence from clinical studies that compromised intestinal
epithelial permeability contributes to the development of nonalcoholic steatohepatitis …

Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are
strategically positioned as immune sentinels poised to respond to invading pathogens in …

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions.
These junctional complexes are related to those found at epithelial junctions but with …

Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes,
and signal transduction, acting as a multifunctional complex in vertebrate epithelial and …