Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R **ang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

Advances in nanomaterial-based platforms to combat COVID-19: Diagnostics, preventions, therapeutics, and vaccine developments

N Mahmud, MI Anik, MK Hossain, MI Khan… - ACS Applied Bio …, 2022 - ACS Publications
The COVID-19 pandemic caused by the SARS-CoV-2, a ribonucleic acid (RNA) virus that
emerged less than two years ago but has caused nearly 6.1 million deaths to date. Recently …

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron

R Maeda, J Fujita, Y Konishi, Y Kazuma… - Communications …, 2022 - nature.com
We are amid the historic coronavirus infectious disease 2019 (COVID-19) pandemic.
Imbalances in the accessibility of vaccines, medicines, and diagnostics among countries …

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity

WH Chen, A Hajduczki, EJ Martinez, H Bai… - Nature …, 2023 - nature.com
Despite rapid and ongoing vaccine and therapeutic development, SARS-CoV-2 continues to
evolve and evade, presenting a need for next-generation diverse therapeutic modalities …

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

J Aguado, AA Amarilla, A Taherian Fard, EA Albornoz… - Nature aging, 2023 - nature.com
Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019
(COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to …

Integrative overview of antibodies against SARS-CoV-2 and their possible applications in COVID-19 prophylaxis and treatment

NA Valdez-Cruz, E García-Hernández, C Espitia… - Microbial cell …, 2021 - Springer
SARS-CoV-2 is a novel β-coronavirus that caused the COVID-19 pandemic disease, which
spread rapidly, infecting more than 134 million people, and killing almost 2.9 million thus far …

A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments

J Li, CB Howard, S Dey, K Lowry, DM Whiley… - Nature …, 2023 - nature.com
Accurate and early detection of biomarkers provides the molecular evidence for disease
management, allowing prompt actions and timely treatments to save lives. Multivalent …

A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19

J Huo, H Mikolajek, A Le Bas, JJ Clark… - Nature …, 2021 - nature.com
SARS-CoV-2 remains a global threat to human health particularly as escape mutants
emerge. There is an unmet need for effective treatments against COVID-19 for which …

[HTML][HTML] NANOBODY® Molecule, a Giga Medical Tool in Nanodimensions

S Kunz, M Durandy, L Seguin, CC Feral - International Journal of …, 2023 - mdpi.com
Although antibodies remain the most widely used tool for biomedical research, antibody
technology is not flawless. Innovative alternatives, such as Nanobody® molecules, were …

Therapeutic applications of nanobodies against SARS-CoV-2 and other viral infections: Current update

M Bhattacharya, S Chatterjee, SS Lee… - International Journal of …, 2023 - Elsevier
In the last two years, the world encountered the SARS-CoV-2 virus, which is still dominating
the population due to the absence of a viable treatment. To eradicate the global pandemic …