Mammalian in vitro gametogenesis
M Saitou, K Hayashi - Science, 2021 - science.org
BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
[HTML][HTML] Chicken embryo as a model in epigenetic research
M Bednarczyk, A Dunislawska, K Stadnicka… - Poultry Science, 2021 - Elsevier
Epigenetics is defined as the study of changes in gene function that are mitotically or
meiotically heritable and do not lead to a change in DNA sequence. Epigenetic …
meiotically heritable and do not lead to a change in DNA sequence. Epigenetic …
[HTML][HTML] In vitro reconstitution of epigenetic reprogramming in the human germ line
Y Murase, R Yokogawa, Y Yabuta, M Nagano, Y Katou… - Nature, 2024 - nature.com
Epigenetic reprogramming resets parental epigenetic memories and differentiates
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …
primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia. This process …
In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells
Mammalian male germ-cell development consists of three distinct phases: primordial germ
cell (PGC) development, male germ-cell specification for spermatogonium development …
cell (PGC) development, male germ-cell specification for spermatogonium development …
Generation of human oogonia from induced pluripotent stem cells in vitro
C Yamashiro, K Sasaki, Y Yabuta, Y Kojima… - Science, 2018 - science.org
Human in vitro gametogenesis may transform reproductive medicine. Human pluripotent
stem cells (hPSCs) have been induced into primordial germ cell–like cells (hPGCLCs); …
stem cells (hPSCs) have been induced into primordial germ cell–like cells (hPGCLCs); …
MEIOSIN directs the switch from mitosis to meiosis in mammalian germ cells
K Ishiguro, K Matsuura, N Tani, N Takeda, S Usuki… - Developmental cell, 2020 - cell.com
The mechanisms regulating meiotic initiation in mammals are enigmatic. It is known that
retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is …
retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is …
ZGLP1 is a determinant for the oogenic fate in mice
INTRODUCTION Mammals generate sexually dimorphic germ cells, oocytes and
spermatozoa, which form the basis for sexual reproduction. Studies in mice have shown that …
spermatozoa, which form the basis for sexual reproduction. Studies in mice have shown that …
[HTML][HTML] Mouse oocytes develop in cysts with the help of nurse cells
W Niu, AC Spradling - Cell, 2022 - cell.com
Mouse germline cysts, on average, develop into six oocytes supported by 24 nurse cells that
transfer cytoplasm and organelles to generate a Balbiani body. We showed that between …
transfer cytoplasm and organelles to generate a Balbiani body. We showed that between …
STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells
R Shimada, Y Kato, N Takeda, S Fujimura… - Nature …, 2023 - nature.com
Meiosis is differently regulated in males and females. In females, germ cells initiate meiosis
within a limited time period in the fetal ovary and undergo a prolonged meiotic arrest until …
within a limited time period in the fetal ovary and undergo a prolonged meiotic arrest until …
Sex-specific chromatin remodelling safeguards transcription in germ cells
Stability of the epigenetic landscape underpins maintenance of the cell-type-specific
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …
transcriptional profile. As one of the main repressive epigenetic systems, DNA methylation …