Long-lived emissive probes for time-resolved photoluminescence bioimaging and biosensing

KY Zhang, Q Yu, H Wei, S Liu, Q Zhao… - Chemical …, 2018‏ - ACS Publications
In this Review article, we systematically summarize the design and applications of various
kinds of long-lived emissive probes for bioimaging and biosensing via time-resolved …

Advanced techniques for detecting protein misfolding and aggregation in cellular environments

Y Bai, S Zhang, H Dong, Y Liu, C Liu… - Chemical Reviews, 2023‏ - ACS Publications
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

The development of ruthenium (II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

FE Poynton, SA Bright, S Blasco, DC Williams… - Chemical Society …, 2017‏ - pubs.rsc.org
Ruthenium (II)[Ru (II)] polypyridyl complexes have been the focus of intense investigations
since work began exploring their supramolecular interactions with DNA. In recent years …

Interrogating amyloid aggregates using fluorescent probes

A Aliyan, NP Cook, AA Martí - Chemical reviews, 2019‏ - ACS Publications
Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …

Ruthenium (II) polypyridyl complexes and DNA—from structural probes to cellular imaging and therapeutics

MR Gill, JA Thomas - Chemical Society Reviews, 2012‏ - pubs.rsc.org
In the last few decades, coordination complexes based on d6 metal centres and polypyridyl
ligand architectures been developed as structure-and site-specific reversible DNA binding …

Fluorescent probes for bioimaging of potential biomarkers in Parkinson's disease

L Gao, W Wang, X Wang, F Yang, L **e… - Chemical Society …, 2021‏ - pubs.rsc.org
Parkinson's disease (PD), as the second most common neurodegenerative disease, is
caused by complex pathological processes and currently remains very difficult to treat. PD …

Recent advances in electrochemical biosensors for the detection of Aβ42, a biomarker for Alzheimer disease diagnosis

M Ding, S Ding, D Du, X Wang, X Hu, P Guan… - TrAC Trends in …, 2023‏ - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a long latency in
the" prodromal" stage, for which there are currently no effective treatments. It is generally …

Recent advances in luminescent heavy metal complexes for sensing

DL Ma, VPY Ma, DSH Chan, KH Leung, HZ He… - Coordination Chemistry …, 2012‏ - Elsevier
Luminescent metal complexes have attracted increasing attention in the literature over the
last few decades. In particular, transition metal compounds have been widely studied for …

Rational Design of Crystallization‐Induced‐Emission Probes To Detect Amorphous Protein Aggregation in Live Cells

D Shen, W **, Y Bai, Y Huang, H Lyu… - Angewandte …, 2021‏ - Wiley Online Library
Unlike amyloid aggregates, amorphous protein aggregates with no defined structures have
been challenging to target and detect in a complex cellular milieu. In this study, we rationally …

Ruthenium (II) complexes with dppz: from molecular photoswitch to biological applications

G Li, L Sun, L Ji, H Chao - Dalton Transactions, 2016‏ - pubs.rsc.org
The DNA photoswitch [Ru (bpy) 2dppz] 2+(bpy= 2, 2′-bipyridine, dppz= dipyrido [3, 2-a:
2′, 3′-c] phenazine) has attracted much attention and become a powerful tool for studying …