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Pathophysiology and treatment of pulmonary hypertension in sickle cell disease
VR Gordeuk, OL Castro… - Blood, The Journal of the …, 2016 - ashpublications.org
Pulmonary hypertension affects∼ 10% of adult patients with sickle cell disease (SCD),
particularly those with the homozygous genotype. An increase in pulmonary artery systolic …
particularly those with the homozygous genotype. An increase in pulmonary artery systolic …
Cardiomyopathy with restrictive physiology in sickle cell disease
Objectives: The aim of this study was to identify a unifying cardiac pathophysiology that
explains the cardiac pathological features in sickle cell disease (SCD). Background …
explains the cardiac pathological features in sickle cell disease (SCD). Background …
Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia
Sickle cell anemia (SCA)–related cardiomyopathy is characterized by diastolic dysfunction
and hyperdynamic features. Diastolic dysfunction portends early mortality in SCA. Diastolic …
and hyperdynamic features. Diastolic dysfunction portends early mortality in SCA. Diastolic …
Cardiovascular complications of sickle cell disease
V Sachdev, DR Rosing, SL Thein - Trends in cardiovascular medicine, 2021 - Elsevier
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States,
and a global health problem. Pathological features of the abnormal hemoglobin (HbS) result …
and a global health problem. Pathological features of the abnormal hemoglobin (HbS) result …
Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology
Cardiopulmonary complications are the leading cause of mortality in sickle cell anemia
(SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and …
(SCA). Elevated tricuspid regurgitant jet velocity, pulmonary hypertension, diastolic, and …
Cardiovascular manifestations of sickle cell disease
N Hammoudi, F Lionnet, A Redheuil… - European heart …, 2020 - academic.oup.com
Sickle cell disease (SCD) is the most frequent genetic haemoglobinopathy worldwide. Early
childhood mortality has dramatically decreased in high-income countries, and most patients …
childhood mortality has dramatically decreased in high-income countries, and most patients …
IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias
Early initiation of disease-modifying therapy can impede or prevent diffuse myocardial fibrosis in sickle cell anemia
Cardiovascular disease is a major cause of mortality in patients with sickle cell disease
(SCD). Niss et al previously reported that cardiac magnetic resonance in 25 patients showed …
(SCD). Niss et al previously reported that cardiac magnetic resonance in 25 patients showed …