Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules
between the informational level of nucleic acids and the functional level of proteins. They …

MODOMICS is a database of RNA modifications that provides comprehensive information
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

Polyamines are primordial polycations found in most cells and perform different functions in
different organisms. Although polyamines are mainly known for their essential roles in cell …

Posttranscriptional modifications of transfer RNAs (tRNAs) are critical for all core aspects of
tRNA function, such as folding, stability, and decoding. Most tRNA modifications were …

Most of the phylogenetic diversity of life is found in bacteria and archaea, and is reflected in
the diverse metabolism and functions of bacterial and archaeal polyamines. The polyamine …

Post-transcriptional modification of RNA is an important determinant of RNA quality control,
translational efficiency, RNA-protein interactions and stress response. This is illustrated by …

Polyamines are evolutionarily ancient polycations derived from amino acids and are
pervasive in all domains of life. They are essential for cell growth and proliferation in …