Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

Molecular dynamics simulations capture the behavior of biological macromolecules in full
atomic detail, but their computational demands, combined with the challenge of …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …

Signal transduction originates at the membrane, where the clustering of signaling proteins is
a key step in transmitting a message. Membranes are difficult to study, and their influence on …

Cholesterol is a key component of cell membranes with a proven modulatory role on the
function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal …

Crucial as molecular sensors for many vital physiological processes, seven-transmembrane
domain G protein-coupled receptors (GPCRs) comprise the largest family of proteins …

Are lipid interactions with membrane proteins best described in terms of the physical
properties of the lipid bilayer or in terms of direct molecular interactions between particular …

Lipids rafts are considered to be functional nanoscale membrane domains enriched in
cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell …