Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

Since its outbreak in 2019, COVID‐19 becomes a pandemic, severely burdening the public
healthcare systems and causing an economic burden. Thus, societies around the world are …

Human spermatogenesis is a highly ordered process; however, the roles of DNA
methylation and chromatin accessibility in this process remain largely unknown. Here by …

The continuous regeneration of spermatogonial stem cells (SSCs) underpins
spermatogenesis and lifelong male fertility, but the developmental origins of the SSC pool …

Spermatogenesis carries the task of precise intergenerational transmission of genetic
information from the paternal genome and involves complex developmental processes …

Male germ cell development requires precise regulation of gene activity in a cell-type and
stage-specific manner, with perturbations in gene expression during spermatogenesis …

Primordial germ cells (PGCs) are the early embryonic precursors of gametes–sperm and
egg cells. PGC-like cells (PGCLCs) can currently be derived in vitro from pluripotent cells …

Abstract Anti-CDK4/6 therapy has been employed for the treatment for head and neck
squamous cell carcinoma (HNSCC) with CDK4/6 hyperactivation, but the response rate is …

Arginine methylation, catalyzed by the protein arginine methyltransferases (PRMTs), is a
common post-translational protein modification (PTM) that is engaged in a plethora of …

Highlights•Epigenome regulating gene expression programs underlies male germ cell
identity and spermatogenesis.•Epigenetic priming ensure the maintenance of male germ …