Spinal cord injury and loss of cortical inhibition

B Benedetti, A Weidenhammer, M Reisinger… - International Journal of …, 2022‏ - mdpi.com
After spinal cord injury (SCI), the destruction of spinal parenchyma causes permanent
deficits in motor functions, which correlates with the severity and location of the lesion …

Preferential activation of unique motor cortical networks with transcranial magnetic stimulation: a review of the physiological, functional, and clinical evidence

GM Opie, JG Semmler - Neuromodulation: Technology at the Neural …, 2021‏ - Elsevier
Objectives The corticospinal volley produced by application of transcranial magnetic
stimulation (TMS) over primary motor cortex consists of a number of waves generated by …

Reticulospinal contributions to gross hand function after human spinal cord injury

SN Baker, MA Perez - Journal of Neuroscience, 2017‏ - Soc Neuroscience
Multiple descending motor pathways likely contribute to the recovery of hand motor function
following spinal cord injury (SCI). Reticulospinal neurons project to spinal motor neurons …

Multisite Hebbian plasticity restores function in humans with spinal cord injury

HJ Jo, E Kizziar, S Sangari, D Chen… - Annals of …, 2023‏ - Wiley Online Library
Objective Spinal cord injury (SCI) damages synaptic connections between corticospinal
axons and motoneurons of many muscles, resulting in devastating paralysis. We …

Potentiating paired corticospinal-motoneuronal plasticity after spinal cord injury

KL Bunday, MA Urbin, MA Perez - Brain stimulation, 2018‏ - Elsevier
Background Paired corticospinal-motoneuronal stimulation (PCMS) increases corticospinal
transmission in humans with chronic incomplete spinal cord injury (SCI) …

[HTML][HTML] Targeted-plasticity in the corticospinal tract after human spinal cord injury

L Christiansen, MA Perez - Neurotherapeutics, 2018‏ - Elsevier
Spinal cord injury (SCI) often results in impaired or absent sensorimotor function below the
level of the lesion. Recent electrophysiological studies in humans with chronic incomplete …

Ipsilesional motor cortex plasticity participates in spontaneous hindlimb recovery after lateral hemisection of the thoracic spinal cord in the rat

AR Brown, M Martinez - Journal of Neuroscience, 2018‏ - Soc Neuroscience
After an incomplete spinal cord injury (SCI) spontaneous motor recovery can occur in
mammals, but the underlying neural substrates remain poorly understood. The motor cortex …

A novel cortical target to enhance hand motor output in humans with spinal cord injury

J Long, P Federico, MA Perez - Brain, 2017‏ - academic.oup.com
A main goal of rehabilitation strategies in humans with spinal cord injury is to strengthen
transmission in spared neural networks. Although neuromodulatory strategies have targeted …

Age‐related changes in late I‐waves influence motor cortex plasticity induction in older adults

GM Opie, J Cirillo, JG Semmler - The Journal of physiology, 2018‏ - Wiley Online Library
Key points The response to neuroplasticity interventions using transcranial magnetic
stimulation (TMS) is reduced in older adults, which may be due, in part, to age‐related …

Evidence for subcortical plasticity after paired stimulation from a wearable device

M Germann, SN Baker - Journal of Neuroscience, 2021‏ - Soc Neuroscience
Existing non-invasive stimulation protocols can generate plasticity in the motor cortex and its
corticospinal projections; techniques for inducing plasticity in subcortical circuits and …